ArticleCurrent nutrition reports2016
The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis.
Article in Current nutrition reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 50 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Vitamin K2 Supplements on Recovery of Lower Limb Muscle Function After Ankle Injury in Adults
Health Effects of Vitamin K2 Supplementation on Skeletal Muscle and Neurological Function After Ischemic Stroke
Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.
- Association of vitamin K with cardiovascular events and all-cause mortality: a systematic review and meta-analysis.European journal of nutrition · 2019Pooled it
- The Effects of Vitamin K2 on Recovery from Muscle-Damaging Resistance Exercise in Young and Older Adults: The TAKEOVER Randomized Controlled Trial.Medicine and science in sports and exercise · 2026Trial
- Trial
- Epigenome-wide association study reveals a molecular signature of response to phylloquinone (vitamin K1) supplementation.Epigenetics · 2020Trial
- Effect of Vitamin K2 on Postural Sway in Older People Who Fall: A Randomized Controlled Trial.Journal of the American Geriatrics Society · 2019Trial
- Fecal concentrations of bacterially derived vitamin K forms are associated with gut microbiota composition but not plasma or fecal cytokine concentrations in healthy adults.The American journal of clinical nutrition · 2017Trial
- Estropausal gut microbiota transplant improves measures of ovarian function in adult mice.Nature aging · 2026Article
- Vitamin K and muscle health: mechanisms and clinical perspectives in sarcopenia and beyond: narrative review.Frontiers in nutrition · 2026Review
- Lipid-Modulating Effects ofNutrients · 2025Article
- Enhancement of menaquinone- 7 production through immobilization with hydrogel-based porous membranes.Applied microbiology and biotechnology · 2025Article
- Alteration of salivaryFrontiers in pharmacology · 2025Article
- Association of dietary vitamin K1 intake with epilepsy in adults in US: a cross-sectional study of National Health and Nutrition Examination Survey 2013-2018.BMC public health · 2024Article
- Colorimetric screening model for identification of menaquinone-7 (MK-7) producing strains.3 Biotech · 2024Article
- Vitamin K: Infection, Inflammation, and Auto-Immunity.Journal of inflammation research · 2024Review
- A Case Control Study Evaluating the Relationship between Vitamin K2 Serum Level and Periodontitis.Healthcare (Basel, Switzerland) · 2023Article
- Structural and non-structural proteins in SARS-CoV-2: potential aspects to COVID-19 treatment or prevention of progression of related diseases.Cell communication and signaling : CCS · 2023Review
- Vitamin K and the Visual System-A Narrative Review.Nutrients · 2023Review
- The Pleiotropic Role of Vitamin K in Multimorbidity of Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2023Review
- Role of Vitamin K in Bone and Muscle Metabolism.Calcified tissue international · 2023Review
- Determination of vitamin K encapsulated into lipid nanocarriers by dispersive liquid-liquid microextraction combined with liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.Food science & nutrition · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin K is an enzyme cofactor required for the carboxylation of vitamin K dependent proteins, several of which have been implicated in diseases of aging. Inflammation is recognized as a crucial component of many chronic aging diseases and evidence suggests vitamin K has an anti-inflammatory action that is independent of its role as an enzyme co-factor. Vitamin K-dependent proteins and inflammation have been implicated in cardiovascular disease and osteoarthritis, which are leading causes of disability and mortality in older adults. The purpose of this review is to summarize observational studies and randomized trials focused on vitamin K status and inflammation, cardiovascular disease, and osteoarthritis. Although mechanistic evidence suggests a protective role for vitamin K in these age-related conditions, the benefit of vitamin K supplementation is controversial because observational data are equivocal and the number of randomized trials is few.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.