ArticleAmerican journal of translational research2016
Rodent model choice has major impact on variability of standard preclinical readouts associated with diabetes and obesity research.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Metabolic dysfunction-associated steatotic liver disease and steatohepatitis-associated hepatocarcinoma preclinical models.Nature reviews. Gastroenterology & hepatology · 2026Review
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- Morphological phenotyping of the aging cochlea in inbred C57BL/6N and outbred CD1 mouse strains.Aging cell · 2025Article
- Comparison of Preimplantation Mouse Embryos with Different Genetic Backgrounds as Models for Evaluating Human Embryo Culture Media Composition.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Supervised machine learning of outbred mouse genotypes to predict hepatic immunological tolerance of individuals.Scientific reports · 2024Article
- Advancing mouse models for transplantation research.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Characterization of excretory/secretory products of the Taenia crassiceps cysticercus involved in the induction of regulatory T cells in vivo.Parasitology research · 2023Article
- Mouse Models of Gestational Diabetes Mellitus and Its Subtypes: Recent Insights and Pitfalls.International journal of molecular sciences · 2023Review
- Differences in lipid metabolism in acquired versus preexisting glucose intolerance during gestation: role of free fatty acids and sphingosine-1-phosphate.Lipids in health and disease · 2022Article
- Building a healthy mouse model ecosystem to interrogate cancer biology.Disease models & mechanisms · 2022Article
- An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity.Physiology & behavior · 2022Article
- Glucose-Stimulated Calcium Dynamics in Beta Cells From Male C57BL/6J, C57BL/6N, and NMRI Mice: A Comparison of Activation, Activity, and Deactivation Properties in Tissue Slices.Frontiers in endocrinology · 2022Article
- Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat.Neurobiology of stress · 2021Article
- Article
- Bridging the Translational Divide in Pain Research: Biological, Psychological and Social Considerations.Frontiers in pharmacology · 2021Review
- Reproducibility of animal research in light of biological variation.Nature reviews. Neuroscience · 2020Article
- TL1A regulates adipose-resident innate lymphoid immune responses and enables diet-induced obesity in mice.International journal of obesity (2005) · 2020Article
- Inhalation of welding fumes reduced sperm counts and high fat diet reduced testosterone levels; differential effects in Sprague Dawley and Brown Norway rats.Particle and fibre toxicology · 2020Article
- Generation of embryonic stem cells derived from the inner cell mass of blastocysts of outbred ICR mice.Animal cells and systems · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laboratory rodents are available as either genetically defined inbred strains or genetically undefined outbred stocks. As outbred rodents are generally thought to display a higher level of phenotypic variation compared to inbred strains, it has been argued that experimental studies should preferentially be performed by using inbred rodents. However, very few studies with adequate sample sizes have in fact compared phenotypic variation between inbred strains and outbred stocks of rodents and moreover, these studies have not reached consistent conclusions. The aim of the present study was to compare the phenotypic variation in commonly used experimental readouts within obesity and diabetes research, for four of the most frequently used mouse strains: inbred C57BL/6 and BALB/c and outbred NMRI and CD-1 mice. The variation for all readouts was examined by calculating the coefficient of variation (CV), i.e., the relative variation, including a 95% confidence interval for the CV. We observed that for the majority of the selected readouts, inbred and outbred mice showed comparable phenotypic variation. The observed variation appeared highly influenced by strain choice and type of readout, which suggests that these collectively would serve as more predictive of the phenotypic variation than the more general classification of mice as inbred or outbred based on genetic heterogeneity.
Indexed as
Identifiers
27648148PMC5009410What OpenQuestion holds
Registered trials
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