ArticleAmerican journal of translational research2016
MicroRNA-494 inhibits proliferation and metastasis of osteosarcoma through repressing insulin receptor substrate-1.
Article in American journal of translational research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Long noncoding RNA ADIRF antisense RNA 1 upregulates insulin receptor substrate 1 to decrease the aggressiveness of osteosarcoma by sponging microRNA-761.Bioengineered · 2022Article
- miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma.Frontiers in pharmacology · 2022Review
- Circ_0081001 down-regulates miR-494-3p to enhance BACH1 expression and promotes osteosarcoma progression.Aging · 2021Article
- Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis.Journal of orthopaedic surgery and research · 2021Article
- Prognostic and Therapeutic Utility of Variably Expressed Cell Surface Receptors in Osteosarcoma.Sarcoma · 2021Article
- MicroRNA-494 represses osteosarcoma development by modulating ASK-1 related apoptosis complexes.Translational cancer research · 2020Article
- miRNA signatures in childhood sarcomas and their clinical implications.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2019Review
- miR-491-5p inhibits osteosarcoma cell proliferation by targeting PKM2.Oncology letters · 2018Article
- Identification of invasion-metastasis-associated microRNAs in hepatocellular carcinoma based on bioinformatic analysis and experimental validation.Journal of translational medicine · 2018Article
- Deep RNA sequencing reveals the dynamic regulation of miRNA, lncRNAs, and mRNAs in osteosarcoma tumorigenesis and pulmonary metastasis.Cell death & disease · 2018Article
- SH2B1 promotes epithelial-mesenchymal transition through the IRS1/β-catenin signaling axis in lung adenocarcinoma.Molecular carcinogenesis · 2018Article
- MicroRNA-194-3p inhibits the metastatic biological behaviors of spinal osteosarcoma cells by the repression of matrix metallopeptidase 9.International journal of clinical and experimental pathology · 2018Article
- MicroRNA-494-3p Promotes Cell Growth, Migration, and Invasion of Nasopharyngeal Carcinoma by Targeting Sox7.Technology in cancer research & treatment · 2018Article
- Long non-coding RNA CRNDE sponges miR-384 to promote proliferation and metastasis of pancreatic cancer cells through upregulating IRS1.Cell proliferation · 2017Article
- MiR-429 suppresses the progression and metastasis of osteosarcoma by targeting ZEB1.EXCLI journal · 2017Article
Corrections and comments
- Retraction · 2022-07-15Investigation by Third Party · Original Data and/or Images not Provided and/or not Available · Paper Mill · Results Not Reproducible · · see also: https://pubpeer.com/publications/C5B48ED5483390A4FC5BCD89CD64B6
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite microRNA-494 (miR-494) has a well-established role in many types of cancer; the biological function and potential mechanism of miR-494 in human osteosarcoma (OS) has not been elucidated. The aim of this study was therefore to investigate the role and underlying mechanism of miR-494 expression in osteosarcoma. Here, we found that miR-494 was significantly decreased in OS tissues and cell lines compared to the adjacent noncancerous bone tissues (P<0.01) and human normal osteoblast cells (NHOst) (P<0.05), respectively. Functional assays demonstrated that ectopic overexpression of miR-494 could significantly inhibit cell proliferation, colony formation, migration and invasion in vitro, as well as suppress tumor growth in nude mice model. Further integrative and functional studies suggested insulin receptor substrate 1 (IRS1) as a target gene of miR-494 in OS cells. IRS1 expression was upregulated, and inversely correlated with miR-494 expression in clinical OS tissues (r=-0.589, P=0.001). Moreover, downregulation of IRS1 had similar the inhibition effect on cell proliferation, colony formation, migration and invasion of miR-494 overexpression. Overexpresion of miR-494 obviously decreased AKT signal pathway activation. These findings suggested that miR-494 functioned as a tumor suppressor in OS, at least in part, by targeting IRS1.
Indexed as
Identifiers
27648134PMC5009396W2535540203What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.