ArticleCardiorenal medicine2016
Brain Natriuretic Peptide and Body Fluid Composition in Patients with Chronic Kidney Disease: A Cross-Sectional Study to Evaluate the Relationship between Volume Overload and Malnutrition.
Article in Cardiorenal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Trial
- Could Serum CA125 Aid the Clinical Assessment of Volume Status of End-Stage Kidney Disease Patients Treated by Peritoneal Dialysis Patients?Blood purification · 2026Article
- Brain natriuretic peptide is a biomarker of atrial fibrillation in hemodialysis patients.Renal failure · 2025Observational
- Plasma B-type natriuretic peptide is independently associated with cardiovascular events and mortality in patients with chronic kidney disease.Scientific reports · 2024Article
- Correlation between cognitive impairment and body composition indicators in patients with chronic kidney disease after hemodialysis.American journal of translational research · 2024Article
- Associations of N-terminal pro-B-type natriuretic peptide, estimated glomerular filtration rate, and mortality in US adults.American heart journal · 2023Article
- B-type natriuretic peptide levels and volume status in twice-weekly hemodialysis patients.Renal failure · 2021Article
- Cerebral oxygen saturation (rSOJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2021Article
- Brain natriuretic peptide reflects individual variation in hydration status in hemodialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2019Article
- Article
- Brain Natriuretic Peptide Is a Marker of Fluid Overload in Incident Hemodialysis Patients.Cardiorenal medicine · 2017Article
- Article
- Utility of bioelectrical phase angle for cardiovascular risk assessment among individuals with and without diabetes mellitus.Diabetes & vascular disease researchArticle
- Insights into the role of extracellular-to-total body water ratio on neurocognitive decrements over time in Asians with type 2 diabetes.Journal of Alzheimer's disease reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimFluid volume overload occurs in chronic kidney disease (CKD), leading to the compensatory release of natriuretic peptides. However, the elevated cardiac peptides may also be associated with malnutrition as well as volume overload.
methodsBody fluid composition was measured in 147 patients with CKD between 2009 and 2015, and its relationship to brain natriuretic peptide (BNP) levels was examined. Body fluid composition was separated into three components: (a) a water-free mass consisting of muscle, fat, and minerals; (b) intracellular water (ICW) content, and (c) extracellular water (ECW) content. Excess fluid mass was calculated using Chamney's formula.
resultsThe measured BNP levels in the tertile groups were 10.9 ± 5.4, 36.3 ± 12.5, and 393 ± 542 pg/ml, respectively. Patients in a higher log-transformed BNP level tertile were more likely to be older, to have a higher frequency of cardiac comorbidities, pulse pressure, C-reactive protein levels, and proteinuria, and to have lower serum sodium, kidney function, and serum albumin (p < 0.05). In body fluid composition, decreased body mass was significantly associated with the ECW-to-ICW ratio in relation to the downward ICW slope (r = -0.235, p = 0.004) and was strongly correlated with excess fluid mass (r = -0.701, p < 0.001). The ECW-to-ICW ratio and excess fluid mass was independently associated with the BNP levels.
conclusionFluid volume imbalance between intra- and extracellular water regulated by decreased cell mass was independently associated with BNP levels, which may explain the reserve capacity for fluid accumulation in patients with CKD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.