Evidence map›Paper›PMID 27648011›Full record

ArticleCardiorenal medicine2016

Genetic Variants in Toll-Like Receptor 4 Gene and Their Association Analysis with Estimated Glomerular Filtration Rate in Mexican American Families.

Farook Thameem, Sobha Puppala, Vidya S Farook, Balakuntalam S Kasinath, John Blangero, Ravindranath Duggirala, Hanna E Abboud

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiorenal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Farook ThameemDivision of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA; Department of Biochemistry, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Sobha PuppalaDepartment of Genetics, Texas Biomedical Research Institute, San Antonio, Tex, USA.
Vidya S FarookSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Tex., and Edinburg, Tex., USA.
Balakuntalam S KasinathDivision of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA; South Texas Veterans Healthcare System, San Antonio, Tex, USA.
John BlangeroSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Tex., and Edinburg, Tex., USA.
Ravindranath DuggiralaSouth Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, Tex., and Edinburg, Tex., USA.
Hanna E AbboudDivision of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Tex, USA; South Texas Veterans Healthcare System, San Antonio, Tex, USA.
The University of Texas Health Science Center at San Antonio · USThe University of Texas Rio Grande Valley · USTexas Biomedical Research Institute · US

Funding

NIDDM SUSCEPTIBILITY GENES IN MEXICAN-AMERICANSR01DK047482 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEHMAN, DONNA M · 1993 to 2010
$5.4M
Transgenic Animal and Morphology CoreP50DK061597 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ABBOUD, HANNA E · 2003 to 2007
$5.0M
GENETICS OF GALLBLADDER DISEASE IN MEXICAN AMERICANSR01DK053889 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI DUGGIRALA, RAVINDRANATH · 1998 to 2011
$2.3M
NIDDK NIH HHS P50 DK061597NIDDK NIH HHS R01 DK047482NIDDK NIH HHS R01 DK053889
6 · The paper itself

Abstract

BACKGROUND/

aimToll-like receptor 4 (TLR4) is one of the regulators of the innate immune response. Genetic variations in TLR4 have been associated with inflammatory diseases, including type 2 diabetes. However, to our knowledge, there are no reports on the role of variations in TLR4 in chronic kidney disease susceptibility. The objective of this study is to determine whether the genetic variants in TLR4 are associated with the estimated glomerular filtration rate (eGFR), a measure of renal function.

methodsTo evaluate the association between TLR4 variants and eGFR, we used data obtained from 434 Mexican American participants from the San Antonio Family Diabetes/Gallbladder Study. GFR was estimated using the Modification of Diet in Renal Disease formula. The Asp(299)Gly (rs4986790) and Thr(399)Ile (rs4986791) variants of TLR4 were genotyped using the TaqMan assay. Association analyses between genotypes and eGFR were performed using the measured genotype approach.

resultsOf the two genetic markers examined for association, only the Asp(299)Gly variant of TLR4 exhibited a nominally significant association with eGFR (p = 0.025) after accounting for the covariate effects of age and sex terms, diabetes, duration of diabetes, systolic blood pressure, body mass index, and antihypertensive treatment. Carriers of Gly299 had significantly decreased eGFR values. Although, the Thr(399)Ile variant failed to exhibit a statistically significant association with eGFR, the carriers of Ile399, however, showed a trend towards decrease in eGFR.

conclusionWe show for the first time that Asp(299)Gly variants of TLR4 are associated with decrease in renal function in Mexican Americans.

Indexed as

Asp(299)GlyEstimated glomerular filtration rateMexican Americansrs4986790rs4986791Thr(399)IleToll-like receptor 4

Identifiers

PMID27648011
PMCPMC5020380
OpenAlexW2408340122

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.