Evidence map›Paper›PMID 27647999›Full record

ArticleInternational journal of medical sciences2016

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy.

Cheng-Hsueh Lee, Jiunn-Bey Pao, Te-Ling Lu, Hong-Zin Lee, Yung-Chin Lee, Chia-Chu Liu, Chao-Yuan Huang, Victor C Lin, Chia-Cheng Yu, Hsin-Ling Yin and 2 more

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Article in International journal of medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. In Silico Assessment ofJournal of pharmacopuncture · 2025
    Article
  2. Biomarkers in Localized Prostate Cancer: From Diagnosis to Treatment.International journal of molecular sciences · 2025
    Review
  3. Prostate cancer biomarkers: from early diagnosis to precision treatment.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Cheng-Hsueh LeeDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Jiunn-Bey PaoDepartment of Pharmacy, Linsen Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan;
Te-Ling LuDepartment of Pharmacy, China Medical University, Taichung, Taiwan;
Hong-Zin LeeDepartment of Pharmacy, China Medical University, Taichung, Taiwan;
Yung-Chin LeeDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;; Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Chia-Chu LiuDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;; Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Chao-Yuan HuangDepartment of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;
Victor C LinDepartment of Urology, E-Da Hospital, Kaohsiung, Taiwan;; School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan;
Chia-Cheng YuDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;; Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan;
Hsin-Ling YinDepartment of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;; Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Shu-Pin HuangDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;; Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
Bo-Ying BaoDepartment of Pharmacy, China Medical University, Taichung, Taiwan;; Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan;; Department of Nursing, Asia University, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledBackgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.

methodsWe genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy.

resultsOne SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis.

conclusionOur results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients.

Indexed as

ProstatectomyAgedAllelesCyclooxygenase 2Genetic Association StudiesGenotypeHaplotypesHumansMaleMiddle AgedNeoplasm Recurrence, LocalPolymorphism, Single NucleotidePrognosisProstatic NeoplasmsCyclooxygenase 2PTGS2 protein, humanbiochemical recurrenceinflammation.prostate cancerPTGS2radical prostatectomysingle-nucleotide polymorphism

Identifiers

PMID27647999
PMCPMC5027188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.