ArticleAnnals of neurosciences2016
Heart Rate Variability in Children with Attention-Deficit/Hyperactivity Disorder: A Pilot Study.
Article in Annals of neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Computational analysis of heart rate variability in ASD and ADHD: a systematic review.Frontiers in computational neuroscience · 2026Pooled it
- Impact of fidget devices on anxiety and physiological responses in adults with ADHD.Research in developmental disabilities · 2025Trial
- Observational
- Do Infant Heart Rate Variability and Visual Attention Predict Autism and Concerns for ADHD?Journal of attention disorders · 2025Article
- Autonomic characterization in adults with attention deficit hyperactivity disorder assessed by heart rate variability measurement during a three-behavioral state paradigm: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Comparative study of autonomic function in diabetics and yoga practitioners using Ewing's battery.Journal of family medicine and primary care · 2025Article
- Heart Rate Variability Biofeedback Intervention Programme to Improve Attention in Primary Schools.Applied psychophysiology and biofeedback · 2024Article
- Machine learning-enabled detection of attention-deficit/hyperactivity disorder with multimodal physiological data: a case-control study.BMC psychiatry · 2024Observational
- Reliability of an "At-Home" Method for Monitoring Resting and Reactive Autonomic Nervous System Activity in Children: A Pilot Study.Children (Basel, Switzerland) · 2024Article
- Examining Heterogeneity in Short-Term Memory via Autonomic Nervous System Functioning Among Youth with ADHD: A Replication and Extension.Journal of psychopathology and behavioral assessment · 2024Article
- Subjective and Autonomic Arousal toward Emotional Stimuli in Preadolescents with Externalizing Problems and the Role of Explicit and Implicit Emotion Regulation.Brain sciences · 2024Article
- Central Autonomic Network and Heart Rate Variability in Premature Neonates.Developmental neuroscience · 2024Article
- Superior Vena Cava Flow in Children With Attention Deficit Hyperactivity Disorder.Psychiatry investigation · 2023Article
- Effectiveness of yoga on Ewing's battery autonomic function test: cross-sectional study.International journal of physiology, pathophysiology and pharmacology · 2023Article
- Short-term exposure to ultrafine and fine particulate matter with multipollutant modelling on heart rate variability among seniors and children from the CorPuScula (coronary, pulmonary, sanguis) longitudinal study in Germany.Frontiers in epidemiology · 2023Article
- Prenatal smoking and drinking are associated with altered newborn autonomic functions.Pediatric research · 2023Article
- Higher scores on autonomic symptom scales in pediatric patients with neurodevelopmental disorders of known genetic etiology.Brain and behavior · 2022Article
- Cardiac Evaluation of Exercise Testing in a Contemporary Population of Preschool Children: A New Approach Providing Reference Values.Children (Basel, Switzerland) · 2022Article
- Orexin/Hypocretin System Dysfunction in ESSENCE (Early Symptomatic Syndromes Eliciting Neurodevelopmental Clinical Examinations).Neuropsychiatric disease and treatment · 2022Article
- Early transient dysautonomia predicts the risk of infantile epileptic spasm syndrome onset: A prospective cohort study.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAttention deficit/hyperactivity disorder (ADHD) is a common childhood neuropsychiatric disorder. Autonomic nervous system plays a vital role in attention, self-regulation, emotional stability and social affiliation, which are affected in ADHD. The prefrontal cortex, which is vital for attention, motor control, emotional regulation and higher order autonomic control, is hypofunctional in ADHD. In addition, catecholamine dysregulation is there. PURPOSE: We hypothesized that there is autonomic dysfunction: reduction in overall heart rate variability (HRV) and sympathovagal imbalance in children with ADHD.
methodsStudy criteria were drug-naïve ADHD children who were 7-12 years of age of either gender who fulfilled DSM-IV criteria for ADHD and did not have any associated comorbid psychiatric/neurological/medical disorders. Two hundred and seventy ADHD children were screened out of which only 12 were found eligible and 10 participated. Sample size was 20 (cases = 10, age- and gender-matched healthy controls = 10). Short-term HRV of both time and frequency domains were assessed by recording lead II electrocardiogram after using Tell-Show-Do, a behavior shaping technique. Comparison between groups was done using Mann-Whitney and Wilcoxon test. Demographic variables like age, height, weight and body mass index were similar between groups.
resultsAmong time domain parameters, SD of all NN intervals, square root of the mean of the sum of squares of differences between adjacent NN intervals and percentage of count of number of pairs of adjacent NN intervals differing by more than 50 ms were reduced in ADHD group with p < 0.05. Among frequency domain parameters, total power was reduced in ADHD group with p < 0.05, high frequency power (HF) was reduced in ADHD group with p < 0.01 and low frequency power to HF ratio was higher in ADHD group with p < 0.01.
conclusionThere is autonomic dysfunction in children with ADHD - reduction in overall HRV with sympathovagal imbalance with sympathetic dominance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.