Evidence map›Paper›PMID 27647918›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Cyclic-nucleotide-gated cation current and Ca2+-activated Cl current elicited by odorant in vertebrate olfactory receptor neurons.

Rong-Chang Li, Yair Ben-Chaim, King-Wai Yau, Chih-Chun Lin

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.8field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The CaThe Journal of physiology · 2024
    Article
  5. Article
  6. Review
  7. Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. CaProceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  12. Article
  13. Article
  14. Article
  15. CaProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  16. Article
  17. Article
  18. Article
  19. Profile of King-Wai Yau.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  20. Smelling better with chloride.Proceedings of the National Academy of Sciences of the United States of America · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rong-Chang LiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Yair Ben-ChaimSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
King-Wai YauSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; kwyau@jhmi.edu clin2@houstonmethodist.org.
Chih-Chun LinSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Neuroscience Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205 kwyau@jhmi.edu clin2@houstonmethodist.org.
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

Cyclic AMP- and Ca2+-Signaling in Sensory Transduction by Olfactory Receptor NeuronsR01DC014941 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI KING-WAI YAU · 2016 to 2026
$3.8M
NIDCD NIH HHS R01 DC014941
6 · The paper itself

Abstract

Olfactory transduction in vertebrate olfactory receptor neurons (ORNs) involves primarily a cAMP-signaling cascade that leads to the opening of cyclic-nucleotide-gated (CNG), nonselective cation channels. The consequent Ca

Indexed as

AnimalsCalciumChloride ChannelsChloridesCyclic AMPCyclic Nucleotide-Gated Cation ChannelsMiceOdorantsOlfactory Receptor NeuronsSignal TransductionSmellCalciumChloride ChannelsChloridesCyclic AMPCyclic Nucleotide-Gated Cation Channelscalcium-activated chloride channelcyclic-nucleotide–gated channelolfactory receptor neuronsolfactory transductionsignal amplification

Identifiers

PMID27647918
PMCPMC5056050
OpenAlexW2522720077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.