Evidence map›Paper›PMID 27647906›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2016

Molecular mechanism of Zn2+ inhibition of a voltage-gated proton channel.

Feng Qiu, Adam Chamberlin, Briana M Watkins, Alina Ionescu, Marta Elena Perez, Rene Barro-Soria, Carlos González, Sergei Y Noskov, H Peter Larsson

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Modulators of the Human Voltage-Gated Proton Channel HPharmaceuticals (Basel, Switzerland) · 2025
    Review
  5. Hv1 channel in immune cells and pharmacology.Pharmacological research · 2025
    Review
  6. Validation of HvFrontiers in cellular neuroscience · 2025
    Article
  7. Article
  8. The sperm-specific KFrontiers in cell and developmental biology · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Cholesterol inhibits human voltage-gated proton channel hHv1.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  14. Review
  15. Expression of HProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Feng QiuDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136.
Adam ChamberlinCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada T2N 2N4.
Briana M WatkinsDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136.
Alina IonescuDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136.
Marta Elena PerezDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136.
Rene Barro-SoriaDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136.
Carlos GonzálezCentro Interdisciplinario de Neurociencias de Valparaiso, Universidad de Valparaiso, Valparaíso 2366103, Chile.
Sergei Y NoskovCentre for Molecular Simulation, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada T2N 2N4; plarsson@med.miami.edu snoskov@ucalgary.ca.
H Peter LarssonDepartment of Physiology and Biophysics, University of Miami, Miami, FL 33136; plarsson@med.miami.edu snoskov@ucalgary.ca.
University of Miami · USUniversity of Calgary · CAUniversity of Valparaíso · CL

Funding

Modulation of KCNQ1 channel activityR01GM109762 · NIGMS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI KASS, ROBERT S, LARSSON, HANS PETER · 2014 to 2022
$3.1M
Molecular mechanisms of voltage-gated proton channelsR01HL095920 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LARSSON, HANS PETER · 2010 to 2013
$1.5M
NHLBI NIH HHS R01 HL095920NIGMS NIH HHS R01 GM109762
6 · The paper itself

Abstract

Voltage-gated proton (Hv1) channels are involved in many physiological processes, such as pH homeostasis and the innate immune response. Zn

Indexed as

AnimalsBinding SitesFemaleFluorometryHumansHydrogen-Ion ConcentrationImmunity, InnateIon Channel GatingIon ChannelsMutationPatch-Clamp TechniquesProtonsXenopus laevisZincHVCN1 protein, humanIon ChannelsProtonsZincHv1inhibitionmolecular modelvoltage-gated proton channelZn2+

Identifiers

PMID27647906
PMCPMC5056077
OpenAlexW2521325152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.