ArticleJournal of the American Society of Nephrology : JASN2017
The Genetic Landscape of Renal Complications in Type 1 Diabetes.
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Article in Journal of the American Society of Nephrology : JASN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 6 of them syntheses that pooled it.
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80citing papers in PubMed, 6 pooled it
12.6field-weighted citation impact, top 1% of its field
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Who cites it
80 citing papers in PubMed, 6 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Nidogen-1 could play a role in diabetic kidney disease development in type 2 diabetes: a genome-wide association meta-analysis.Human genomics · 2022Pooled it
- Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease.Diabetologia · 2022Pooled it
- Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2022Guideline
- Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline.Kidney international · 2021Pooled it
- Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.Scientific reports · 2018Pooled it
- A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes.PloS one · 2018Pooled it
- Multi-omics reveals microbiota, metabolite, and immunological heterogeneity of age-related endotypes in type 1 diabetes.Signal transduction and targeted therapy · 2026Article
- CNDP1 (CTG)Scientific reports · 2026Article
- Gene modification: Exploring the potential in treating kidney diseases.Pharmacological research · 2026Review
- Enhanced Expression of the Female-Biased Gene Gsta2 in Male Proximal Tubule Cells Improves Renal Resilience to Ischemia-Reperfusion Injury.Journal of the American Society of Nephrology : JASN · 2026Article
- Exome-Wide Analysis Identifies a RareKidney international reports · 2026Article
- Genome-Wide Association Studies of Diabetic Kidney Disease in East Asians With Type 2 Diabetes: Achievements and Future Perspectives.Current medicinal chemistry · 2026Review
- Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.Journal of the American Society of Nephrology : JASN · 2025Article
- Role of nuclear receptors, lipid metabolism, and mitochondrial function in the pathogenesis of diabetic kidney disease.American journal of physiology. Renal physiology · 2025Review
- Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.Investigative ophthalmology & visual science · 2025Article
- The Contribution of Genetic Risk and Lifestyle Factors in the Progression of Diabetes to Diabetic Kidney Disease: A Prospective Cohort Study.Journal of diabetes · 2025Article
- Whole Exome Sequencing in 26 Saudi Patients Expands the Mutational and Clinical Spectrum of Diabetic Nephropathy.Medicina (Kaunas, Lithuania) · 2025Article
- Familial clustering of diabetic kidney disease and retinopathy in offspring of parents with type 1 diabetes: a population-based study.EClinicalMedicine · 2025Article
- Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025Review
- Whole-exome and whole-genome sequencing of 1064 individuals with type 1 diabetes reveals novel genes for diabetic kidney disease.Diabetologia · 2024Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
52 authors at 18 institutions in 11 countries.
Niina SandholmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Natalie Van ZuydamWellcome Trust Centre for Human Genetics
Emma AhlqvistDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
Thorhildur JuliusdottirWellcome Trust Centre for Human Genetics
Harshal A DeshmukhDivision of Population Health Sciences, University of Dundee, Dundee, United Kingdom.
N William RaynerWellcome Trust Centre for Human Genetics
Barbara Di CamilloDepartment of Information Engineering, University of Padova, Padova, Italy.
Carol ForsblomFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Joao FadistaDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
Daniel ZiemekComputational Sciences, Pfizer Worldwide Research and Development, Berlin, Germany.
Rany M SalemDepartments of Genetics
Linda T HirakiGenetics and Genome Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada.
Marcus PezzolesiSection on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts.
David TrégouëtSorbonne Universities, Pierre et Marie Curie University (UPMC) and National Institute for Health and Medical Research, Mixed Research Unit in Health (UMR_S) 1166, Paris, France.
Emma DahlströmFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Erkka ValoFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Nikolay OskolkovDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
Claes LadenvallDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
M Loredana MarcovecchioDepartment of Paediatrics, Institute of Metabolic Science, and.
Jason CooperDepartment of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
Francesco SamboDepartment of Information Engineering, University of Padova, Padova, Italy.
Alberto MaloviniDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Marco ManfriniDepartment of Information Engineering, University of Padova, Padova, Italy.
Amy Jayne McKnightNephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, United Kingdom.
Maria LajerDiabetic Complications, Steno Diabetes Center, Gentofte, Denmark.
Valma HarjutsaloFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Daniel GordinFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
Maija ParkkonenFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland.
The FinnDiane Study Group
Jaakko TuomilehtoThe Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland.
Valeriya LyssenkoDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
Paul M McKeigueCentre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Mary Julia BrosnanCardiovascular and Metabolic Diseases Research Unit, and.
Eric FaumanComputational Sciences, Pfizer Worldwide Research and Development, Cambridge, Massachusetts.
Riccardo BellazziDepartment of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.
Peter RossingDiabetic Complications, Steno Diabetes Center, Gentofte, Denmark.
Samy HadjadjFunctional Research Unit of Medicine and Pharmacy, University of Poitiers, Poitiers, France.
Andrzej KrolewskiSection on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts.
Andrew D PatersonGenetics and Genome Biology Program, Hospital for Sick Children, Toronto, Ontario, Canada.
The DCCT/EDIC Study Group
Jose C FlorezPrograms in Metabolism and Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts.
Joel N HirschhornDepartments of Genetics
Alexander P MaxwellNephrology Research, Centre for Public Health, Queen's University of Belfast, Belfast, United Kingdom.
GENIE Consortium
David DungerDepartment of Paediatrics, Institute of Metabolic Science, and.
Claudio CobelliDepartment of Information Engineering, University of Padova, Padova, Italy.
Helen M ColhounDivision of Population Health Sciences, University of Dundee, Dundee, United Kingdom.
Leif GroopDepartment of Clinical Sciences, Diabetes and Endocrinology, Skåne University Hospital, Lund University, Malmö, Sweden.
Mark I McCarthyWellcome Trust Centre for Human Genetics
Per-Henrik GroopFolkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland
SUMMIT Consortium
University of Helsinki · FICentre for Human Genetics · GBLund University · SEUniversity of Padua · ITBroad Institute · USJoslin Diabetes Center · USQueen's University Belfast · GBSteno Diabetes Centers · DKInstitut des Maladies Métaboliques et Cardiovasculaires · FRPfizer (United States) · USUniversity of Copenhagen · DKUniversity of Dundee · GBHospital for Sick Children · CAPfizer (Germany) · DESorbonne Université · FRUniversity of Cambridge · GBUniversity of Pavia · ITUniversity of Virginia · US
Funding
Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6MVector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4MEpidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8MTRAINING IN DIABETES AND METABOLISMT32DK007260 · NIDDK · JOSLIN DIABETES CENTER · PI LAURIE J GOODYEAR · 1986 to 2026
$13.6MIntegrative genomic, epigenetic and functional studies in diabetic kidney diseaseR01DK105154 · NIDDK · BROAD INSTITUTE, INC. · PI FLOREZ, JOSE CARLOS, HIRSCHHORN, JOEL N · 2016 to 2019
$3.0MGenome-Wide Association Studies of Diabetic NephropathyR01DK081923 · NIDDK · BROAD INSTITUTE, INC. · PI HIRSCHHORN, JOEL N · 2009 to 2012
$2.3MMethods for Genetic Association Analysis of Longitudinal and Multiple PhenotypesR00HL122515 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SALEM, RANY · 2017 to 2019
$732kMedical Research Council MC_PC_15025NHLBI NIH HHS R00 HL122515NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK081923NIDDK NIH HHS R01 DK105154NIDDK NIH HHS T32 DK007260NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176Wellcome Trust
Abstract
Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous efforts in three dimensions, examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional diabetic kidney disease phenotypes. In 2843 subjects, we estimated that the heritability of diabetic kidney disease was 35% (P=6.4×10
Indexed as
AdolescentAdultDiabetes Mellitus, Type 1Diabetic NephropathiesFemaleGenome-Wide Association StudyHumansMaleMiddle AgedYoung Adultdiabetic kidney diseasegenetics and developmentgenome-wide association studywhole exome sequencing
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.