ArticleJournal of immunology (Baltimore, Md. : 1950)2016
Direct IL-6 Signals Maximize Protective Secondary CD4 T Cell Responses against Influenza.
Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed.
- Bidirectional Communication Between the Innate and Adaptive Immune Systems.Annual review of immunology · 2025Review
- Innate immune role of IL-6 in influenza a virus pathogenesis.Frontiers in cellular and infection microbiology · 2025Review
- Systems Immunology Analyses ofImmunoHorizons · 2022Article
- Inflammation, Immune Senescence, and Dysregulated Immune Regulation in the Elderly.Frontiers in aging · 2022Review
- Interplay of Inflammatory, Antigen and Tissue-Derived Signals in the Development of Resident CD8 Memory T Cells.Frontiers in immunology · 2021Review
- Influenza Vaccine-Induced CD4 Effectors Require Antigen Recognition at an Effector Checkpoint to Generate CD4 Lung Memory and Antibody Production.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failure.World journal of gastroenterology · 2020Article
- T-bet optimizes CD4 T-cell responses against influenza through CXCR3-dependent lung trafficking but not functional programming.Mucosal immunology · 2019Article
- Memory CD4 T cell-derived IL-2 synergizes with viral infection to exacerbate lung inflammation.PLoS pathogens · 2019Article
- Activation of naïve CD4Nature immunology · 2019Article
- IL-6 Promotes T Cell Proliferation and Expansion under Inflammatory Conditions in Association with Low-Level RORγt Expression.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Integrative Physiology of Pneumonia.Physiological reviews · 2018Review
- Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity.Cancer science · 2018Review
- The Regulation of Inflammation by Innate and Adaptive Lymphocytes.Journal of immunology research · 2018Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Memory T cells can often respond against pathogens that have evaded neutralizing Abs and are thus key to vaccine-induced protection, yet the signals needed to optimize their responses are unclear. In this study, we identify a dramatic and selective requirement for IL-6 to achieve optimal memory CD4 T cell recall following heterosubtypic influenza A virus (IAV) challenge of mice primed previously with wild-type or attenuated IAV strains. Through analysis of endogenous T cell responses and adoptive transfer of IAV-specific memory T cell populations, we find that without IL-6, CD4
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Registered trials
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