Evidence map›Paper›PMID 27647832›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2016

IDO1 and TGF-β Mediate Protective Effects of IFN-α in Antigen-Induced Arthritis.

Jaya Prakash Chalise, Maria Teresa Pallotta, Sudeep Chenna Narendra, Björn Carlsson, Alberta Iacono, Joanitah Namale, Louis Boon, Ursula Grohmann, Mattias Magnusson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in cellular neuroscience · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. CD83 Regulates the Immune Responses in Inflammatory Disorders.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
  11. The role of indoleamine 2,3 dioxygenase 1 in the osteoarthritis.American journal of translational research · 2020
    Review
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 5 countries.

Jaya Prakash ChaliseDivision of Rheumatology, Autoimmunity, and Immune Regulation, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden; jaya.prakash.chalise@liu.se mattias.magnusson@liu.se.ORCID 0000-0001-6462-2819
Maria Teresa PallottaDepartment of Experimental Medicine, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-0417-1638
Sudeep Chenna NarendraDivision of Rheumatology, Autoimmunity, and Immune Regulation, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden.
Björn CarlssonDivision of Drug Research, Clinical Pharmacology, Department of Medical and Health Sciences, Linköping University, Linköping 58185, Sweden; and.
Alberta IaconoDepartment of Experimental Medicine, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0002-2650-072X
Joanitah NamaleDivision of Rheumatology, Autoimmunity, and Immune Regulation, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden.
Louis BoonEPIRUS Biopharmaceuticals Netherlands BV, 3584 CM Utrecht, the Netherlands.
Ursula GrohmannDepartment of Experimental Medicine, University of Perugia, 06100 Perugia, Italy.ORCID 0000-0001-7952-1850
Mattias MagnussonDivision of Rheumatology, Autoimmunity, and Immune Regulation, Department of Clinical and Experimental Medicine, Linköping University, Linköping 58185, Sweden.ORCID 0000-0002-6565-4027
Linköping University · SEUniversity of Perugia · ITBristol-Myers Squibb (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IFN-α prevents Ag-induced arthritis (AIA), and in this study we investigated the role of IDO1 and TGF-β signaling for this anti-inflammatory property of IFN-α. Arthritis was induced by methylated BSA (mBSA) in mBSA-sensitized wild-type (WT), Ido1

Indexed as

AnimalsArthritis, ExperimentalCell ProliferationCells, CulturedDendritic CellsGene Expression RegulationIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineMiceMice, 129 StrainMice, KnockoutReceptor, Interferon alpha-betaSerum Albumin, BovineSignal TransductionTransforming Growth Factor betaIDO1 protein, mouseIfnar1 protein, mouseIndoleamine-Pyrrole 2,3,-DioxygenaseKynurenineReceptor, Interferon alpha-betaSerum Albumin, BovineTransforming Growth Factor beta

Identifiers

PMID27647832
PMCPMC5055200
OpenAlexW2222423398

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.