ArticleMicrocirculation (New York, N.Y. : 1994)2017
Influence of red blood cell aggregation on perfusion of an artificial microvascular network.
Article in Microcirculation (New York, N.Y. : 1994), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Association Between Intra-Aortic Balloon Pump Support and Whole Blood Viscosity Following Cardiopulmonary Bypass.Artificial organs · 2026Observational
- A Pulsatile Flow-Modulation Microfluidic Sensor for Simultaneous Monitoring of Red Blood Cell Aggregation and Viscosity-Sensitive Time Constant.Sensors (Basel, Switzerland) · 2026Article
- Micro Blood Flow-Resolved Rheometry.Micromachines · 2026Article
- Monitoring micro-rheological and multi-organ microcirculatory changes in abdominal sepsis in rats - a new approach to analyzing microcirculatory videos.Frontiers in physiology · 2026Article
- Hemorheological and microcirculatory effects of Pentaglobin therapy in an experimental model of fulminant sepsis.Frontiers in physiology · 2026Article
- Enhancing outcomes in Langendorff-perfused rodent hearts through perfusion parameter optimization.Scientific reports · 2025Article
- Aggregation and disaggregation of red blood cells: Depletion versus bridging.Biophysical journal · 2025Article
- Gene-environmental influence of space and microgravity on red blood cells with sickle cell disease.NPJ genomic medicine · 2024Review
- Local and Systemic Micro-Rheological Changes during Intestinal Anastomosis Operation: A Metabolic Dependence in an Experimental Model.Metabolites · 2024Article
- Hump-Nosed Pit Viper (Cells · 2024Article
- L-Arginine-eNOS-NO Functional System in Brain Damage and Cognitive Impairments in Cerebral Small Vessel Disease.International journal of molecular sciences · 2023Article
- Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip.Micromachines · 2023Article
- Contributions of Red Blood Cell Sedimentation in a Driving Syringe to Blood Flow in Capillary Channels.Micromachines · 2022Article
- Concurrent Assessment of Deformability and Adhesiveness of Sickle Red Blood Cells by Measuring Perfusion of an Adhesive Artificial Microvascular Network.Frontiers in physiology · 2021Article
- Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device.Transfusion · 2020Article
- Blood rheology biomarkers in sickle cell disease.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Microfluidic-Based Biosensor for Sequential Measurement of Blood Pressure and RBC Aggregation Over Continuously Varying Blood Flows.Micromachines · 2019Article
- Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (Fåhraeus effect) in an artificial microvascular network.Microcirculation (New York, N.Y. : 1994) · 2017Article
- Optimal hematocrit in an artificial microvascular network.Transfusion · 2017Article
- Partitioning of red blood cell aggregates in bifurcating microscale flows.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveRBCs suspended in plasma form multicellular aggregates under low-flow conditions, increasing apparent blood viscosity at low shear rates. It has previously been unclear, however, if RBC aggregation affects microvascular perfusion. Here, we analyzed the impact of RBC aggregation on perfusion and 'capillary' hematocrit in an AMVN at driving pressures ranging from 5 to 60 cm H
methodsRBCs were suspended at 30% hematocrit in either 46.5 g/L dextran 40 (D40, non-aggregating medium) or 35 g/L dextran 70 (D70, aggregating medium) solutions with equal viscosity.
resultsAggregation was readily observed in the AMVN for RBCs suspended in D70 at driving pressures ≤40 cm H
conclusionsWe conclude that although RBC aggregation did not affect the AMVN perfusion rate independently of the driving pressure, a higher hematocrit in the 'capillaries' of the network for D70 suspensions suggested a better oxygen transport capacity in the presence of RBC aggregation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.