ArticleHuman brain mapping2017
Desynchronization of autonomic response and central autonomic network connectivity in posttraumatic stress disorder.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 4 of them syntheses that pooled it.
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Who cites it
46 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Smaller total and subregional cerebellar volumes in posttraumatic stress disorder: a mega-analysis by the ENIGMA-PGC PTSD workgroup.Molecular psychiatry · 2024Pooled it
- Autonomic nervous system correlates of posttraumatic stress symptoms in youth: Meta-analysis and qualitative review.Clinical psychology review · 2022Pooled it
- A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.Frontiers in neuroscience · 2021Pooled it
- Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis.Psychological medicine · 2020Pooled it
- Prenatal Alcohol Exposure: Impact on Neuroimmune Function in the Stress Response and Pain.Advances in experimental medicine and biology · 2026Review
- Disrupted thalamocortical functional connectivity and canonical resting-state network integration in posttraumatic stress disorder.NeuroImage. Clinical · 2026Article
- Functioning Level as a Buffer: Longitudinal Associations Between Heart Rate Variability and Post-Traumatic Stress Disorder Risk Over 2 Years.Psychiatry investigation · 2025Article
- Probing the neurocardiac circuit in trauma and posttraumatic stress.Journal of psychiatric research · 2024Article
- Role of stress and early-life stress in the pathogeny of inflammatory bowel disease.Frontiers in neuroscience · 2024Review
- Impacts of heart rate variability on post-traumatic stress disorder risks after physical injuries: amplification with childhood abuse histories.Frontiers in psychiatry · 2024Article
- Microstates of the cortical brain-heart axis.Human brain mapping · 2023Article
- Norepinephrine release in the cerebellum contributes to aversive learning.Nature communications · 2023Article
- Why art? The role of arts in arts and health.Frontiers in psychology · 2023Article
- Complex Brain-Heart Mapping in Mental and Physical Stress.IEEE journal of translational engineering in health and medicine · 2023Article
- Imaging the cerebellum in post-traumatic stress and anxiety disorders: a mini-review.Frontiers in systems neuroscience · 2023Review
- The cerebellum and psychological trauma: A systematic review of neuroimaging studies.Neurobiology of stress · 2022Review
- A Web-Based Cognitive Behavioral Therapy, Mindfulness Meditation, and Yoga Intervention for Posttraumatic Stress Disorder: Single-Arm Experimental Clinical Trial.JMIR mental health · 2022Article
- Acute-stress-induced change in salience network coupling prospectively predicts post-trauma symptom development.Translational psychiatry · 2022Article
- Structural and functional connections between the autonomic nervous system, hypothalamic-pituitary-adrenal axis, and the immune system: a context and time dependent stress response network.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Comparison of the Cardiovascular Effects of Extreme Psychological and Physical Stress Tests in Male Soccer Players.International journal of environmental research and public health · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAlthough dysfunctional emotion regulatory capacities are increasingly recognized as contributing to posttraumatic stress disorder (PTSD), little work has sought to identify biological markers of this vulnerability. Heart rate variability (HRV) is a promising biomarker that, together with neuroimaging, may assist in gaining a deeper understanding of emotion dysregulation in PTSD. The objective of the present study was, therefore, to characterize autonomic response patterns, and their related neuronal patterns in individuals with PTSD at rest.
methodsPTSD patients (N = 57) and healthy controls (N = 41) underwent resting-state fMRI. Connectivity patterns of key regions within the central autonomic network (CAN)-including the ventromedial prefrontal cortex (vmPFC), amygdala, and periaqueductal gray (PAG)-were examined using a seed-based approach. Observed connectivity patterns were then correlated to resting HRV.
resultsIn contrast to controls, individuals with PTSD exhibited lower HRV. In addition, whereas controls engaged a localized connectivity pattern of CAN-related brain regions, in PTSD, key CAN regions were associated with widespread connectivity patterns in regions related to emotional reactivity (vmPFC and amygdala to insular cortex and lentiform nucleus; PAG to insula) and motor readiness (vmPFC and amygdala to precentral gyrus; PAG to precentral gyrus and cerebellum). Critically, whereas CAN connectivity in controls was strongly related to higher HRV (insula, mPFC, superior frontal cortex, thalamus), HRV covariation was absent in PTSD subjects.
conclusionsThis study provides the first evidence for a specific psychophysiological-neuronal profile in PTSD individuals characterized by lower resting HRV and a lack of HRV covariation with CAN-related brain connectivity. Hum Brain Mapp 38:27-40, 2017. © 2016 Wiley Periodicals, Inc.
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