ArticleAnnals of clinical microbiology and antimicrobials2016
Molecular characterization of Staphylococcus aureus isolates from various healthcare institutions in Nairobi, Kenya: a cross sectional study.
Article in Annals of clinical microbiology and antimicrobials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
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- A 6-Year Update on the Diversity of Methicillin-ResistantFrontiers in microbiology · 2022Review
- Genetic Diversity ofMicroorganisms · 2021Article
- Methicillin-Resistant Coagulase-NegativeThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Genetic diversity and risk factors for the transmission of antimicrobial resistance across human, animals and environmental compartments in East Africa: a review.Antimicrobial resistance and infection control · 2020Review
- Molecular epidemiology of antimicrobial resistant microorganisms in the 21th century: a review of the literature.Acta bio-medica : Atenei Parmensis · 2020Review
- Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.Antibiotics (Basel, Switzerland) · 2019Article
- Phenotypic and genotypic characterization of clinical Staphylococcus aureus isolates from Kenya.BMC microbiology · 2019Article
- Phylogenetic and Molecular Profile ofMicroorganisms · 2019Article
- Methicillin-resistant Staphylococcus aureus (MRSA) in East Africa: red alert or red herring?BMC infectious diseases · 2019Article
- Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.Nature reviews. Microbiology · 2019Review
- Bridging antimicrobial resistance knowledge gaps: The East African perspective on a global problem.PloS one · 2019Article
- A six-member SNP assay on the iPlex MassARRAY platform provides a rapid and affordable alternative for typing major AfricanAccess microbiology · 2019Article
- Antimicrobial Resistance and Molecular Characteristics of Methicillin-resistantInfection and drug resistance · 2019Article
- Distribution of the Most PrevalentFrontiers in microbiology · 2018Review
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Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStaphylococcus aureus (S. aureus) has established itself over the years as a major cause of morbidity and mortality both within the community and in healthcare settings. Methicillin resistant S. aureus (MRSA) in particular has been a major cause of nosocomial infections resulting in significant increase in healthcare costs. In Africa, the MRSA prevalence has been shown to vary across different countries. In order to better understand the epidemiology of MRSA in a setting, it is important to define its population structure using molecular tools as different clones have been found to predominate in certain geographical locations.
methodsWe carried out PFGE, MLST, SCCmec and spa typing of selected S. aureus isolates from a private and public referral hospital in Nairobi, Kenya.
resultsA total of 93 S. aureus isolates were grouped into 19 PFGE clonal complexes (A-S) and 12 singletons. From these, 55 (32 MRSA and 23 MSSA) representative isolates from each PFGE clonal complex and all singletons were spa typed. There were 18 different MRSA spa types and 22 MSSA spa types. The predominant MRSA spa type was t037 comprising 40.6 % (13/32) of all MRSA. In contrast, the MSSA were quite heterogeneous, only 2 out of 23 MSSA shared the same spa type. Two new MRSA spa types (t13149 and t13150) and 3 new MSSA spa types (t13182, t13193 and t13194) were identified. The predominant clonal complex was CC 5 which included multi-locus sequence types 1, 8 and 241.
conclusionIn contrast to previous studies published from Kenya, there's marked genetic diversity amongst clinical MRSA isolates in Nairobi including the presence of well-known epidemic MRSA clones. Given that these clones are resident within our referral hospitals, adherence to strict infection control measures needs to be ensured to reduce morbidity and mortality associated with hospital acquired MRSA infections.
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