Evidence map›Paper›PMID 27647198›Full record

ReviewChinese medical journal2016

Gut Microbiota-brain Axis.

Hong-Xing Wang, Yu-Ping Wang

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chinese medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04366401 (Efficacy of Dietary Modulation With High Prebiotic and Probiotic Content on Nutritional and Metabolic Status in Schizophrenia Spectrum Disorders), which is not on this map. Cited by 248 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
248citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04366401 nacompletednot on this mapstarted 2020, after this paper: background citation

Efficacy of Dietary Modulation With High Prebiotic and Probiotic Content on Nutritional and Metabolic Status in Schizophrenia Spectrum Disorders

TypeinterventionalSponsorUniversidad de CórdobaRan2020 to 2023Enrolled44ConditionsSchizophrenia and Related Disorders, Diet HabitArmsConventional Dietary Advice, Prebiotic/Probiotic Dietary Modulation
3 · Its place in the literature

Who cites it

248 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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  6. WORKbiota: A Systematic Review about the Effects of Occupational Exposure on Microbiota and Workers' Health.International journal of environmental research and public health · 2022
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188 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hong-Xing WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
Yu-Ping WangDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053; Center of Epilepsy, Beijing Institute for Brain Disorders, Laboratory of Brain Disorders, Capital Medical University, Beijing 100069, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically review the updated information about the gut microbiota-brain axis. DATA SOURCES: All articles about gut microbiota-brain axis published up to July 18, 2016, were identified through a literature search on PubMed, ScienceDirect, and Web of Science, with the keywords of "gut microbiota", "gut-brain axis", and "neuroscience". STUDY SELECTION: All relevant articles on gut microbiota and gut-brain axis were included and carefully reviewed, with no limitation of study design.

resultsIt is well-recognized that gut microbiota affects the brain's physiological, behavioral, and cognitive functions although its precise mechanism has not yet been fully understood. Gut microbiota-brain axis may include gut microbiota and their metabolic products, enteric nervous system, sympathetic and parasympathetic branches within the autonomic nervous system, neural-immune system, neuroendocrine system, and central nervous system. Moreover, there may be five communication routes between gut microbiota and brain, including the gut-brain's neural network, neuroendocrine-hypothalamic-pituitary-adrenal axis, gut immune system, some neurotransmitters and neural regulators synthesized by gut bacteria, and barrier paths including intestinal mucosal barrier and blood-brain barrier. The microbiome is used to define the composition and functional characteristics of gut microbiota, and metagenomics is an appropriate technique to characterize gut microbiota.

conclusionsGut microbiota-brain axis refers to a bidirectional information network between the gut microbiota and the brain, which may provide a new way to protect the brain in the near future.

Indexed as

AnimalsBrainCentral Nervous SystemGastrointestinal MicrobiomeGastrointestinal TractHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal System

Identifiers

PMID27647198
PMCPMC5040025

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.