Evidence map›Paper›PMID 27646959›Full record

ReviewSeminars in immunopathology2017

Tolerogenic dendritic cells.

Maisa C Takenaka, Francisco J Quintana

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in immunopathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 175 citations in OpenAlex.

  1. Review
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  15. Targeting Talin1 to reprogram dendritic cell activation landscapes: A mechanistically grounded cell therapy for multiple sclerosis model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  16. Review
  17. Ivy Leaf Dry Extract EA 575Pharmaceutics · 2025
    Article
  18. Review
  19. Review
  20. Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Maisa C TakenakaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA.
Francisco J QuintanaAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA. fquintana@rics.bwh.harvard.edu.ORCID 0000-0001-8156-0736
Brigham and Women's Hospital · USBroad Institute · US

Funding

Role of AHR in Dendritic Cells in the Control of the CNS AutoimmunityR01ES025530 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI Francisco J. Quintana · 2016 to 2026
$3.7M
Role of aryl hydrocarbon receptor in IL-10 producing Tr1 regulatory cellsR01AI093903 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2011 to 2015
$1.9M
Role of aryl hydrocarbon receptor in IL-10 producing Tr1 regulatory cellsR56AI093903 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J. · 2016 to 2016
$413k
Role and Therapeutic Value of AHR in Inflammatory Macrophages during GBMR21NS087867 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI QUINTANA, FRANCISCO J., WEINER, HOWARD L · 2014 to 2015
$259k
NIAID NIH HHS R01 AI093903NIAID NIH HHS R56 AI093903NIEHS NIH HHS R01 ES025530NINDS NIH HHS R21 NS087867
6 · The paper itself

Abstract

Deficits in immunological tolerance against self-antigens and antigens provided by the diet and commensal microbiota can result in the development of inflammatory and autoimmune disorders. Dendritic cells (DCs) are pivotal regulators of the immune response, specialized in antigen presentation to drive T cell priming and differentiation. DCs also have a tolerogenic function, participating in the enforcement of central and peripheral tolerance and the resolution of ongoing immune responses. Thus, DCs control effector and regulatory mechanisms relevant to the pathology of autoimmune disorders. In this review, we discuss recent findings regarding the control of the adaptive immune response by tolerogenic DCs. A thorough understanding of the mechanisms that control the tolerogenic DC phenotype will guide the development of novel strategies for the treatment of autoimmunity.

Indexed as

Immune ToleranceAnimalsAntigen PresentationAutoimmunityBiomarkersCell DifferentiationCell LineageCytokinesDendritic CellsGene ExpressionHistocompatibility Antigens Class IIHumansPerforinReceptors, CholinergicT-Lymphocyte SubsetsBiomarkersCytokinesHistocompatibility Antigens Class IIPerforinReceptors, CholinergicAhRAutoimmunityDendritic cellNanoparticlesTolerance

Identifiers

PMID27646959
PMCPMC5296314
OpenAlexW2522519532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.