Trial reportScientific reports2016
Anterior eye tissue morphology: Scleral and conjunctival thickness in children and young adults.
Trial report in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 86 citations in OpenAlex.
- Long-term results after sutureless intrascleral fixation of the Carlevale intraocular lens: Changes in scleral pocket thickness over time.Acta ophthalmologica · 2025Trial
- Stepwise 900 µm to 1100 µm Microneedle Selection for Suprachoroidal Triamcinolone Acetonide.Journal of vitreoretinal diseases · 2026Article
- Evaluation of anterior scleral thickness in pachychoroid pigment epitheliopathy, central serous chorioretinopathy and pachychoroid neovasculopathy.Japanese journal of ophthalmology · 2026Article
- Regional Tear Film Quality Changes Across Eye Gaze Directions Revealed by Spatial Mapping and Threshold Sensitivity Analysis.Journal of clinical medicine · 2026Article
- Topotecan Microneedle Scleral Patch: A Transscleral Drug Delivery Study for Retinoblastoma.Ophthalmology science · 2026Article
- Thermal Tissue Modeling of the Ciliary Body With Continuous Wave Transscleral Cyclophotocoagulation and Transscleral Laser Therapy Using MicroPulse Technology.Translational vision science & technology · 2025Article
- The Role of Scanning Electron Microscopy in the Evaluation of Conjunctival Microvilli as an Early Biomarker of Ocular Surface Health: A Literature Review.Journal of clinical medicine · 2024Review
- Relationship between Choroidal Thickness and Anterior Scleral Thickness in Patients with Keratoconus.Diagnostics (Basel, Switzerland) · 2024Article
- A detailed survey of the murine limbus, its stem cell distribution, and its boundaries with the cornea and conjunctiva.Stem cells translational medicine · 2024Article
- Anterior Scleral Thickness and Anterior Segment Biometrics Measured with Swept Source Ocular Coherence Tomography in High Myopic Eyes with and without Glaucoma: A Comparative Study.Diagnostics (Basel, Switzerland) · 2024Article
- Biometry-Based Technique for Determining the Anterior Scleral Thickness: Validation Using Optical Coherence Tomography Landmarks.Translational vision science & technology · 2024Article
- Phacoemulsification in Nanophthalmic Eye, a Way to Manage Glaucoma: Case Report.Case reports in ophthalmological medicine · 2024Article
- Assessment of anterior scleral thickness in myopes and emmetropes using anterior segment optical coherence tomography.Molecular vision · 2024Article
- Anterior Scleral Thickness Profile in Keratoconus.Life (Basel, Switzerland) · 2023Article
- The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence.Scientific reports · 2023Article
- The Role of Oxidative Stress in the Aging Eye.Life (Basel, Switzerland) · 2023Review
- Comparison of anterior sclera thickness in emmetropes and myopes.BMC ophthalmology · 2023Article
- Aging Effects on Optic Nerve Neurodegeneration.International journal of molecular sciences · 2023Review
- Scleral changes in systemic lupus erythematosus patients using swept source optical coherence tomography.Frontiers in immunology · 2023Article
- Outcomes of pars plana vitrectomy in three cases of ophthalmomyiasis interna.American journal of ophthalmology case reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sclera and conjunctiva form part of the eye's tough, protective outer coat, and play important roles in the eye's mechanical protection and immune defence, as well as in determining the size and shape of the eye globe. Advances in ocular imaging technology now allow these tissues in the anterior eye to be imaged non-invasively and with high resolution, however there is a paucity of data examining the dimensions of these tissues in paediatric populations. In this study, we have used optical coherence tomography (OCT) imaging to examine the normal in vivo thickness profile of the anterior sclera and overlying conjunctiva in 111 healthy young participants, including a large proportion of paediatric subjects. We demonstrate that the thickness of the anterior sclera varies significantly with measurement location and meridian. Tissue thickness also varied significantly with age, with younger subjects exhibiting significantly thinner scleras and significantly greater conjunctival thickness. Males were also found to exhibit significantly greater scleral thickness. Refractive error however was not significantly associated with either scleral or conjunctival thickness in this population. These findings provide new data describing the normative dimensions of anterior eye tissues in children and the factors that can influence these dimensions in young populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.