ArticleJournal of clinical oncology : official journal of the American Society of Clinical Oncology2016
Vasectomy and Prostate Cancer Incidence and Mortality in a Large US Cohort.
Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Vasectomy and prostate cancer risk: a pooled of cohort studies and Mendelian randomization analysis.BMC cancer · 2025Pooled it
- Association between vasectomy and risk of prostate cancer: a meta-analysis.Prostate cancer and prostatic diseases · 2021Pooled it
- The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis.JAMA internal medicine · 2017Pooled it
- Oesophageal metastasis of prostate cancer: a case report.Discover oncology · 2025Article
- Research Progress on the Functional Regulation Mechanisms of ZKSCAN3.Biomolecules · 2025Review
- The review of the long-term health risks associated with vasectomy.International journal of impotence research · 2025Review
- The Biological Roles of ZKSCAN3 (ZNF306) in the Hallmarks of Cancer: From Mechanisms to Therapeutics.International journal of molecular sciences · 2024Review
- Vasectomy has No Impact on Future Lower Urinary Tract Symptoms Diagnoses: A Retrospective Cohort Claims Database Analysis.JU open plus · 2023Article
- Vasectomy and Risk of Prostate Cancer: A Systematic Review and Meta-analysis.European urology open science · 2022Review
- Review of Vasectomy Complications and Safety Concerns.The world journal of men's health · 2021Review
- Impact of Vasectomy on the Development and Progression of Prostate Cancer: Preclinical Evidence.Cancers · 2020Article
- Vasectomy and Prostate Cancer Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC).Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Re: Vasectomy and Prostate Cancer Incidence and Mortality in a Large US Cohort.European urology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose In a recent large prospective study, vasectomy was associated with modestly higher risk of prostate cancer, especially high-grade and lethal prostate cancer. However, evidence from prospective studies remains limited. Therefore, we assessed the associations of vasectomy with prostate cancer incidence and mortality in a large cohort in the United States. Patients and Methods We examined the association between vasectomy and prostate cancer mortality among 363,726 men in the Cancer Prevention Study II (CPS-II) cohort, of whom 7,451 died as a result of prostate cancer during follow-up from 1982 to 2012. We also examined the association between vasectomy and prostate cancer incidence among 66,542 men in the CPS-II Nutrition Cohort, a subgroup of the CPS-II cohort, of whom 9,133 were diagnosed with prostate cancer during follow-up from 1992 to 2011. Cox proportional hazards regression modeling was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% CIs. Results In the CPS-II cohort, vasectomy was not associated with prostate cancer mortality (HR, 1.01; 95% CI, 0.93 to 1.10). In the CPS-II Nutrition Cohort, vasectomy was not associated with either overall prostate cancer incidence (HR, 1.02; 95% CI, 0.96 to 1.08) or high-grade prostate cancer incidence (HR, 0.91; 95% CI, 0.78 to 1.07 for cancers with Gleason score ≥ 8). Conclusion Results from these large prospective cohorts do not support associations of vasectomy with either prostate cancer incidence or prostate cancer mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.