ReviewJournal of clinical oncology : official journal of the American Society of Clinical Oncology2017
Is Participation in Cancer Phase I Trials Really Therapeutic?
Review in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Risk-Benefit of Phase 2 Monotherapy Trials in Adult Solid Cancers: A Systematic Review and Meta-Analysis.International journal of cancer · 2026Pooled it
- Who should be included in first-in-human trials? A systematic review of reasons.Journal of translational medicine · 2025Pooled it
- Outcomes Among Racial and Ethnic Minority Patients With Advanced Cancers in Phase 1 Trials: A Meta-Analysis.JAMA network open · 2024Pooled it
- Risk and surrogate benefit for pediatric Phase I trials in oncology: A systematic review with meta-analysis.PLoS medicine · 2018Pooled it
- Risk and benefit for targeted therapy agents in paediatric phase I trials in oncology: a systematic review and meta-analysis protocol.BMJ open · 2026Article
- Use of supportive care services and advance care planning among early phase oncology clinical trial participants.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Assessing the risks and benefits of investigational new drugs in adult phase-I oncology trials in China, 2013-2021.Investigational new drugs · 2025Review
- Feasibility Testing of an APRN-Led Model of Care for Transition of Patients After Completion of Phase I Trials.Journal of the advanced practitioner in oncology · 2025Article
- Proportion of patients in phase 2 oncology trials receiving treatments that are ultimately approved.Journal of the National Cancer Institute · 2025Article
- Decision-making and autonomy among participants in early-phase cancer immunotherapy trials: a qualitative study.BMC cancer · 2024Article
- Ethical Criteria for Improved Human Subject Protections in Phase I Healthy Volunteer Trials.Ethics & human research · 2022Article
- Early drug development in solid tumours: analysis of National Cancer Institute-sponsored phase 1 trials.Lancet (London, England) · 2022Article
- Trends in Grade 5 Toxicity and Response in Phase I Trials in Hematologic Malignancy: 20-Year Experience From the Cancer Therapy Evaluation Program at the National Cancer Institute.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022Article
- Recruitment, outcomes, and toxicity trends in phase I oncology trials: Six-year experience in a large institution.Cancer reports (Hoboken, N.J.) · 2022Article
- Do the Potential Medical Benefits of Phase 1 Pediatric Oncology Trials Justify the Risks? Views of the United States Public.The Journal of pediatrics · 2021Article
- Ethical Challenges in Pediatric Oncology Care and Clinical Trials.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2021Article
- Proportion of Patients in Phase I Oncology Trials Receiving Treatments That Are Ultimately Approved.Journal of the National Cancer Institute · 2020Article
- Reply to 'Correcting the ASCO position on phase I clinical trials in cancer'.Nature reviews. Clinical oncology · 2020Article
- Before Consent: Qualitative Analysis of Deliberations of Patients With Advanced Cancer About Early-Phase Clinical Trials.JCO oncology practice · 2020Article
- Phase I trials as valid therapeutic options for patients with cancer.Nature reviews. Clinical oncology · 2019Review
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.