Evidence map›Paper›PMID 27646878›Full record

ReviewAllergy2017

Immunopathology alters Th17 cell glucocorticoid sensitivity.

J Banuelos, Y Cao, S C Shin, N Z Lu

Abstract readReview
In one paragraph

Review in Allergy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed.

  1. The emerging role of T cells in depression.Frontiers in psychiatry · 2026
    Review
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  15. Article
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  18. The protective capability ofFrontiers in immunology · 2022
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J BanuelosDivision of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Y CaoDivision of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
S C ShinDivision of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
N Z LuDivision of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9M
Glucocorticosteroid Action In Inflammatory DiseaseR37HL068546 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SCHLEIMER, ROBERT P · 2009 to 2018
$3.5M
Glucocorticoids and glucocorticoid receptor translational isoformsR21AI113935 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LU, NICK · 2014 to 2015
$425k
NCI NIH HHS P30 CA060553NHLBI NIH HHS R37 HL068546NIAID NIH HHS R21 AI113935
6 · The paper itself

Abstract

Th17 cells contribute to several inflammatory conditions and increasing evidence supports that Th17 cells are glucocorticoid resistant. However, Th17 cells in psoriasis and related diseases are glucocorticoid sensitive. We compare glucocorticoid sensitive and resistant immunological diseases and suggest that several aspects in Th17-related diseases alter glucocorticoid sensitivity of Th17 cells. We identify molecular pathways that are implicated in glucocorticoid sensitivity of Th17 cells in the literature, as this information is useful for developing approaches to overcome glucocorticoid-resistant immunopathology.

Indexed as

Drug ToleranceAnimalsAnti-Inflammatory AgentsCell DifferentiationCytokinesDisease SusceptibilityGene Expression RegulationGlucocorticoidsHumansImmune System DiseasesInflammationSignal TransductionTh17 CellsT-Lymphocyte SubsetsAnti-Inflammatory AgentsCytokinesGlucocorticoidsasthmaautoimmunityglucocorticoid resistanceglucocorticoidsTh17 cells

Identifiers

PMID27646878
PMCPMC5315659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.