ArticleNature communications2016
Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 47 citations in OpenAlex.
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- Activity-driven myelin sheath growth is mediated by mGluR5.Nature neuroscience · 2025Article
- Behavioral, metabolic, and biochemical alterations caused by an acute stress event in a zebrafish larvae model.Fish physiology and biochemistry · 2025Article
- Early-life challenge enhances cortisol regulation in zebrafish larvae.Biology open · 2024Article
- Neuropeptidergic regulation of neuromuscular signaling in larval zebrafish alters swimming behavior and synaptic transmission.iScience · 2024Article
- Cortisol dynamics and GR-dependent feedback regulation in zebrafish larvae exposed to repeated stress.Biology open · 2024Article
- Response of CRH system in brain and gill of marine medaka to seawater acidification.Fish physiology and biochemistry · 2024Article
- High-resolution tracking of unconfined zebrafish behavior reveals stimulatory and anxiolytic effects of psilocybin.Molecular psychiatry · 2024Article
- Saccades and pivoting during positive mechanotaxis in larval zebrafish.microPublication biology · 2024Article
- Constant Conversion Rate of Endolysosomes Revealed by a pH-Sensitive Fluorescent Probe.ACS sensors · 2023Article
- Altered glucocorticoid reactivity and behavioral phenotype in rx3-/- larval zebrafish.Frontiers in endocrinology · 2023Article
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- Optogenetic approaches for understanding homeostatic and degenerative processes in Drosophila.Cellular and molecular life sciences : CMLS · 2021Review
- The Effects of Early Life Stress on the Brain and Behaviour: Insights From Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- Neuromodulation and Behavioral Flexibility in Larval Zebrafish: From Neurotransmitters to Circuits.Frontiers in molecular neuroscience · 2021Article
- Visual-looming Shadow Task withBio-protocol · 2020Article
- Chronic unpredictable stress induces anxiety-like behaviors in young zebrafish.Scientific reports · 2020Article
- Paraventricular nucleus CRH neurons encode stress controllability and regulate defensive behavior selection.Nature neuroscience · 2020Article
- Neurobiological links between stress and anxiety.Neurobiology of stress · 2019Review
- Imaging and Manipulating Pituitary Function in the Awake Mouse.Endocrinology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anterior pituitary is the major link between nervous and hormonal systems, which allow the brain to generate adequate and flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid in coping with acutely threatening environments. For this we combine optogenetic manipulation of pituitary corticotroph cells in larval zebrafish with newly developed assays for measuring goal-directed actions in very short timescales. Our results reveal modulatory actions of corticotroph cell activity on locomotion, avoidance behaviours and stimulus responsiveness directly after the onset of stress. Altogether, the findings uncover the significance of endocrine pituitary cells for rapidly optimizing behaviour in local antagonistic environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.