SynthesisDiabetologia2016
Pre-eclampsia is associated with a twofold increase in diabetes: a systematic review and meta-analysis.
Synthesis in Diabetologia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Integrating Social and Clinical Determinants of Pre-Eclampsia: A Hierarchical Systematic Review and Conceptual Framework for Prevention.BJOG : an international journal of obstetrics and gynaecology · 2026Pooled it
- Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review.BMC medicine · 2024Pooled it
- Risk of type 2 diabetes mellitus in women with prior hypertensive disorders of pregnancy: a systematic review and meta-analysis.Diabetologia · 2021Pooled it
- Trial
- Therapeutic Interventions for Preeclampsia: Integrating Placental and Maternal Perspectives.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Review
- Overlap of Gestational Diabetes Mellitus and Pre-eclampsia: A Scoping Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2026Review
- Context-dependent features of transcriptomic landscapes in pregnant mother-neonate dyads of preeclampsia.Clinical and experimental pediatrics · 2026Article
- Preeclampsia and Onset of Renal Disorders in the Long-Term Period following Pregnancy.American journal of nephrology · 2026Article
- Pregnancy complications and risk of cardiometabolic-renal conditions in 1.4 million women in England: longitudinal study.BMJ medicine · 2026Article
- The Impact of Preeclampsia and Gestational Diabetes on Future Maternal Cardiometabolic Health.Acta physiologica (Oxford, England) · 2025Review
- Frequent Use of Premenopausal Progestin in Women With Prior Preeclampsia.The Journal of clinical endocrinology and metabolism · 2025Article
- Clinical implications of a history of pre-eclampsia in women with type two diabetes mellitus.Diabetic medicine : a journal of the British Diabetic Association · 2025Article
- Metabolic outcomes in women 6 months and 2 years after preeclampsia versus normotensive pregnancy: A P4 study.Clinical obesity · 2025Article
- Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study.International journal of women's health · 2025Article
- Adverse pregnancy outcomes and risk of type 2 diabetes in postmenopausal women.American journal of obstetrics and gynecology · 2024Article
- Pregnancy complications and later life women's health.Acta obstetricia et gynecologica Scandinavica · 2023Review
- Article
- Effectiveness of a nurse practitioner-led cardiovascular prevention clinic at reduction of metabolic syndrome following maternal complications of pregnancy: a preliminary analysis.Diabetology & metabolic syndrome · 2022Article
- Hypertensive Disorders of Pregnancy and Heart Failure Risk.Current hypertension reports · 2022Review
- New strategies and therapies for the prevention of heart failure in high-risk patients.Clinical cardiology · 2022Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
aims/hypothesisPre-eclampsia is a pregnancy-specific multisystem disorder and a state of physiological insulin resistance. Our aim was to systematically evaluate and quantify the evidence on the relationship between pre-eclampsia and the future risk of diabetes.
methodsWe conducted a systematic review and meta-analysis of studies that evaluated diabetes in women with and without pre-eclampsia. We performed a systematic search of MEDLINE and EMBASE to identify relevant studies. Independent double data extractions were conducted by four reviewers. Random-effects meta-analysis was used to estimate the risk of future diabetes following pre-eclampsia.
resultsA total of 21 studies were identified with more than 2.8 million women, including more than 72,500 women with pre-eclampsia. Meta-analysis of studies that adjusted for potential confounders demonstrated that pre-eclampsia was independently associated with an increased risk of future diabetes (RR 2.37 [95% CI 1.89, 2.97]). This risk appeared in studies that followed women from less than 1 year postpartum (RR 1.97 [95% CI 1.35, 2.87]) and persisted to more than 10 years postpartum (RR 1.95 [95% CI 1.28, 2.97]). After adjusting for BMI or gestational diabetes, pre-eclampsia remained linked with an increased risk of future diabetes (RR 2.38 [95% CI 1.74, 3.24] and RR 2.36 [95% CI 1.94, 2.88], respectively). CONCLUSIONS/
interpretationPre-eclampsia is independently associated with a twofold increase in future diabetes. Our study highlights the importance of clinical risk assessment for the future development of diabetes in women with pre-eclampsia. We recommend detailed evaluation of a screening programme for diabetes in this high-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.