ArticleHearing research2016
Hearing sensitivity differs between zebrafish lines used in auditory research.
Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Impacts of variation in experimental parameters on larval zebrafish behavior: Enhancing rigor and reproducibility in neurobehavioral research.Behavioural processes · 2026Article
- Hearing thresholds in European sea bass (Dicentrarchus labrax): new insights into auditory sensitivity.Fish physiology and biochemistry · 2026Article
- Experimental reporting of fish transcriptomic responses in environmental toxicology and ecotoxicology.Environmental toxicology and chemistry · 2025Review
- Cognitive dynamics of drug-mediated zebrafish under sound stimuli in a microfluidic environment.Biomicrofluidics · 2025Article
- Preclinical Models to Study the Molecular Pathophysiology of Meniere's Disease: A Pathway to Gene Therapy.Journal of clinical medicine · 2025Article
- PEPITA: Parallelized High-Throughput Quantification of Ototoxicity and Otoprotection in Zebrafish Larvae.Bio-protocol · 2024Article
- Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish (International journal of molecular sciences · 2024Article
- Age-related changes in the zebrafish and killifish inner ear and lateral line.Scientific reports · 2024Article
- Finite element modelling of sound transmission in the Weberian apparatus of zebrafish (Journal of the Royal Society, Interface · 2024Article
- Article
- Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles.eLife · 2022Article
- The effect of time regime in noise exposure on the auditory system and behavioural stress in the zebrafish.Scientific reports · 2022Article
- Dnmt1 is required for the development of auditory organs via cell cycle arrest and Fgf signalling.Cell proliferation · 2022Article
- Detecting Novel Ototoxins and Potentiation of Ototoxicity by Disease Settings.Frontiers in neurology · 2021Review
- Naringin attenuates cisplatin- and aminoglycoside-induced hair cell injury in the zebrafish lateral line via multiple pathways.Journal of cellular and molecular medicine · 2021Article
- Zebrafish breeding program: genetic parameters estimates for growth traits.Journal of applied genetics · 2019Article
- Article
- PI3K and Inhibitor of Apoptosis Proteins Modulate Gentamicin- Induced Hair Cell Death in the Zebrafish Lateral Line.Frontiers in cellular neuroscience · 2017Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Zebrafish are increasingly used in auditory studies, in part due to the development of several transgenic lines that express hair cell-specific fluorescent proteins. However, it is largely unknown how transgene expression influences auditory phenotype. We previously observed reduced auditory sensitivity in adult Brn3c:mGFP transgenic zebrafish, which express membrane-bound green fluorescent protein (GFP) in sensory hair cells. Here, we examine the auditory sensitivity of zebrafish from multiple transgenic and background strains. We recorded auditory evoked potentials in adult animals and observed significantly higher auditory thresholds in three lines that express hair cell-specific GFP. There was no obvious correlation between hair cell density and auditory thresholds, suggesting that reduced sensitivity was not due to a reduction in hair cell density. FM1-43 uptake was reduced in Brn3c:mGFP fish but not in other lines, suggesting that a mechanotransduction defect may be responsible for the auditory phenotype in Brn3c animals, but that alternate mechanisms underlie the increased AEP thresholds in other lines. We found reduced prepulse inhibition (a measure of auditory-evoked behavior) in larval Brn3c animals, suggesting that auditory defects develop early in this line. We also found significant differences in auditory sensitivity between adults of different background strains, akin to strain differences observed in mouse models of auditory function. Our results suggest that researchers should exercise caution when selecting an appropriate zebrafish transgenic or background strain for auditory studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.