Evidence map›Paper›PMID 27646833›Full record

ArticleStem cell reviews and reports2016

The Effects of Pharmacological Compounds on Beat Rate Variations in Human Long QT-Syndrome Cardiomyocytes.

Jukka Kuusela, Jiyeong Kim, Esa Räsänen, Katriina Aalto-Setälä

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reviews and reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. IBiomedicines · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jukka KuuselaInstitute of Biomedical Technology, University of Tampere, Tampere, Finland.ORCID 0000-0002-3327-2403
Jiyeong KimDepartment of Physics, Tampere University of Technology, Tampere, Finland.
Esa RäsänenDepartment of Physics, Tampere University of Technology, Tampere, Finland.
Katriina Aalto-SetäläInstitute of Biomedical Technology, University of Tampere, Tampere, Finland. katriina.aalto-setala@uta.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Healthy human heart rate fluctuates overtime showing long-range fractal correlations. In contrast, various cardiac diseases and normal aging show the breakdown of fractal complexity. Recently, it was shown that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) intrinsically exhibit fractal behavior as in humans. Here, we investigated the fractal complexity of hiPSC-derived long QT-cardiomyocytes (LQT-CMs). We recorded extracellular field potentials from hiPSC-CMs at baseline and under the effect of various compounds including β-blocker bisoprolol, ML277, a specific and potent I

Indexed as

Adrenergic beta-1 Receptor AntagonistsAdultBisoprololCells, CulturedDose-Response Relationship, DrugFemaleFractalsHeart Conduction SystemHeart RateHumansInduced Pluripotent Stem CellsLong QT SyndromeMyocytes, CardiacPiperidinesThiazolesTime FactorsAdrenergic beta-1 Receptor AntagonistsBisoprololPiperidines(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamideThiazolesTosyl CompoundsCardiomyocytesDetrended fluctuation analysisFractalsInduced pluripotent stem cellLong QT syndromeMultielectrode arrayNonlinear dynamics

Identifiers

PMID27646833
PMCPMC5106508

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.