Evidence map›Paper›PMID 27646703›Full record

ArticleG3 (Bethesda, Md.)2016

Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability During

Yuting Deng, Iva Greenwald

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Positive autoregulation ofDevelopment (Cambridge, England) · 2020
    Article
  4. Biology of theGenetics · 2019
    Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yuting DengDepartment of Biological Sciences, Columbia University, New York 10027.
Iva GreenwaldDepartment of Biological Sciences, Columbia University, New York 10027 isg4@columbia.edu.
Columbia University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
CELL, MOLECULAR AND DEVELOPMENTAL BIOLOGY OF CANCERT32CA009503 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GAUTIER, JEAN · 1985 to 2016
$6.8M
New modes and mechanisms of negative regulation of LIN-12/Notch in C. elegansR01GM114140 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENWALD, IVA S · 2015 to 2018
$1.4M
NCI NIH HHS T32 CA009503NIGMS NIH HHS R01 GM114140NIH HHS P40 OD010440
6 · The paper itself

Abstract

Upon ligand binding, the LIN-12/Notch intracellular domain is released from its transmembrane tether to function in a nuclear complex that activates transcription of target genes. During

Indexed as

C. elegansNotch

Identifiers

PMID27646703
PMCPMC5100865
OpenAlexW2528252924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.