Evidence map›Paper›PMID 27646281›Full record

ReviewWorld journal of surgery2017

Collective Review of the Status of Rapid Sequence Intubation Drugs of Choice in Trauma in Low- and Middle-Income Settings (Prehospital, Emergency Department and Operating Room Setting).

Leressè Pillay, Timothy Hardcastle

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in World journal of surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04291521 (Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes), which is not on this map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04291521 withdrawnnot on this mapstarted 2027, after this paper: background citation

Prospective Study of Induction Medications Used in the Rapid Sequence Intubation of Trauma Patients and a Comparison of Effects on Outcomes

TypeobservationalSponsorUniversity of Southern CaliforniaRan2027 to 2029Enrolled0ConditionsTrauma, Rapid Sequence IntubationArmsKetamine, Etomidate, Propofol
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Guideline
  2. Guideline
  3. Pooled it
  4. Trial
  5. Trial
  6. Article
  7. The process of rapid sequence intubation in the prehospital setting: A scoping review.The Southern African journal of critical care : the official journal of the Critical Care Society · 2025
    Review
  8. Review
  9. Article
  10. Introductory Overview: IATSIC Symposium, WJS.World journal of surgery · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Leressè PillayDepartment of Anaesthetics, Inkosi Albert Luthuli Central Hospital, Mayville, Durban, KwaZulu-Natal, South Africa. leresse@gmail.com.
Timothy HardcastleTrauma Unit, Inkosi Albert Luthuli Central Hospital, 800 Vusi Mzimela Rd, Mayville, Durban, 4058, KwaZulu-Natal, South Africa.
University of KwaZulu-Natal · ZA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEstablishing a definitive airway in order to ensure adequate ventilation and oxygenation is an important aspect of resuscitation of the polytrauma patient .

aimTo review the relevant literature that compares the different drugs used for rapid sequence intubation (RSI) of trauma patients, specifically reviewing: premedication, induction agents and neuromuscular blocking agents across the prehospital, emergency department and operating room setting, and to present the best practices based on the reviewed evidence.

methodA literature review of rapid sequence intubation in the trauma population was carried out, specifically comparison of the drugs used (induction agent, neuromuscular blocking drugs and adjuncts). DISCUSSION: Studies involving the comparison of drugs used in RSI in, specifically, the trauma patient are sparse. The majority of studies have compared induction agents, etomidate, ketamine and propofol, as well as the neuromuscular blocking agents, succinylcholine and rocuronium.

conclusionThere currently exists great variation in the practice of RSI; however, in trauma the RSI armamentarium is limited to agents that maintain hemodynamic stability, provide adequate intubating conditions in the shortest time period and do not have detrimental effects on cerebral perfusion pressure. Further, multicenter randomized controlled studies to confirm the benefits of the currently used agents in trauma are required.

Indexed as

Developing CountriesAdultAndrostanolsAnesthetics, DissociativeAnesthetics, IntravenousEmergency Service, HospitalEtomidateHumansIntubation, IntratrachealKetamineMultiple TraumaNeuromuscular Nondepolarizing AgentsOperating RoomsPropofolRocuroniumSuccinylcholineAndrostanolsAnesthetics, DissociativeAnesthetics, IntravenousEtomidateKetamineNeuromuscular Nondepolarizing AgentsPropofolRocuroniumSuccinylcholine

Identifiers

PMID27646281
OpenAlexW2522477319

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.