Trial reportMolecular psychiatry2017
Depression, daily stressors and inflammatory responses to high-fat meals: when stress overrides healthier food choices.
Trial report in Molecular psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- The relationship between dairy products intake and breast cancer incidence: a meta-analysis of observational studies.BMC cancer · 2021Pooled it
- Afternoon distraction: a high-saturated-fat meal and endotoxemia impact postmeal attention in a randomized crossover trial.The American journal of clinical nutrition · 2020Trial
- Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation.Psychoneuroendocrinology · 2018Trial
- Healthy Lifestyle and Time to Depression Onset in Individuals With and Without Incident Stroke: A Longitudinal Analysis Using UK Biobank Data.Alpha psychiatry · 2026Article
- Article
- Cross-sectional associations between CES-D scores and the salivary metabolome in nonclinical adults.Discover mental health · 2026Article
- Psychological profile and heart rate variability in adults with self-perceived chronic stress: secondary analysis from a clinical trial.Frontiers in physiology · 2026Article
- Effects of Walnuts on Postprandial Cognitive Function in Adults With Subjective Cognitive Impairment: Protocol for a Randomized Crossover Trial.JMIR research protocols · 2025Article
- How the Dietary Saturated/Monounsaturated Fatty Acid Ratio Modulates Brain Function in Older Adults.Nutrients · 2025Review
- Writing tips for psychoneuroimmunology trainees: Lessons learned from Dr. Kiecolt-Glaser.Comprehensive psychoneuroendocrinology · 2024Article
- Psychoneuroimmunology and the research of Janice Kiecolt-Glaser: It informs self-care and the practice of medicine.Comprehensive psychoneuroendocrinology · 2024Review
- A social science: Using psychoneuroimmunology principles to promote career longevity, productivity, and meaning.Comprehensive psychoneuroendocrinology · 2024Article
- Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder.Foods (Basel, Switzerland) · 2022Review
- Antioxidant Biomolecules and Their Potential for the Treatment of Difficult-to-Treat Depression and Conventional Treatment-Resistant Depression.Antioxidants (Basel, Switzerland) · 2022Review
- Biological mechanisms underlying widowhood's health consequences: Does diet play a role?Comprehensive psychoneuroendocrinology · 2021Review
- The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring.Translational psychiatry · 2021Article
- Multiple lifestyle factors and depressed mood: a cross-sectional and longitudinal analysis of the UK Biobank (N = 84,860).BMC medicine · 2020Article
- A meta-review of "lifestyle psychiatry": the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2020Article
- Food and mood: how do diet and nutrition affect mental wellbeing?BMJ (Clinical research ed.) · 2020Article
- Psychosocial, behavioral and clinical correlates of children with overweight and obesity.BMC pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Depression, stress and diet can all alter inflammation. This double-blind, randomized crossover study addressed the impact of daily stressors and a history of major depressive disorder (MDD) on inflammatory responses to high-fat meals. During two separate 9.5 h admissions, 58 healthy women (38 breast cancer survivors and 20 demographically similar controls), mean age 53.1 years, received either a high saturated fat meal or a high oleic sunflower oil meal. The Daily Inventory of Stressful Events assessed prior day stressors and the Structured Clinical Interview for DSM-IV evaluated MDD. As expected, for a woman with no prior day stressors, C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule-1 (sICAM-1) and vascular cell adhesion molecule-1 (sVCAM-1) were higher following the saturated fat meal than the high oleic sunflower oil meal after controlling for pre-meal measures, age, trunk fat and physical activity. But if a woman had prior day stressors, these meal-related differences disappeared-because the stressors heightened CRP, SAA, sICAM-1 and sVCAM-1 responses to the sunflower oil meal, making it look more like the responses to the saturated fat meal. In addition, women with an MDD history had higher post-meal blood pressure responses than those without a similar history. These data show how recent stressors and an MDD history can reverberate through metabolic alterations, promoting inflammatory and atherogenic responses.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.