Trial reportJournal of substance abuse treatment2017
Anhedonia Is Associated with Poorer Outcomes in Contingency Management for Cocaine Use Disorder.
Trial report in Journal of substance abuse treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 4 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Efficacy and safety of pharmacological interventions for the treatment of cocaine use disorder: A systematic review and network meta-analysis.Addiction (Abingdon, England) · 2026Pooled it
- Comparison of Treatments for Cocaine Use Disorder Among Adults: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Assessment of Anhedonia in Adults With and Without Mental Illness: A Systematic Review and Meta-analysis.JAMA network open · 2020Pooled it
- "I's" on the prize: A systematic review of individual differences in Contingency Management treatment response.Journal of substance abuse treatment · 2019Pooled it
- Undervaluing nondrug rewards or overvaluing cocaine? Cocaine demand relates to cocaine use severity more strongly than anhedonia in individuals with cocaine use disorder.Experimental and clinical psychopharmacology · 2025Trial
- Exploring the Role of Reward Functioning in the Overlap of Post-Traumatic Stress and Cocaine Use Disorder.Substance use & misuse · 2025Trial
- Variation in cocaine responses across genetically diverse mouse strains.Psychopharmacology · 2026Article
- Decisional incentive sensitivity is linked to contingency management outcome and striatal dopamine signaling in individuals with cocaine use disorder: a preliminary study.Addiction and substance abuse · 2026Article
- The late positive potential predicts contingency management outcomes for cocaine use disorder.Drug and alcohol dependence · 2025Article
- Affect-laden risk profiles derived from two days of EMA predict substance use and quality of life three- and six-months after SUD treatment.Journal of substance use and addiction treatment · 2025Article
- Deficits in consummatory reward relate to severity of cocaine use.Drug and alcohol dependence · 2023Article
- A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.Nutrients · 2022Review
- The effect of ketamine on anhedonia: improvements in dimensions of anticipatory, consummatory, and motivation-related reward deficits.Psychopharmacology · 2022Review
- Negative symptoms in alcohol use disorder: A pilot study applying the two-factor model of negative symptoms to patients with alcohol use disorder.Frontiers in psychiatry · 2022Article
- Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward.Pharmacology, biochemistry, and behavior · 2021Review
- I feel good? Anhedonia might not mean "without pleasure" for people treated for opioid use disorder.Journal of abnormal psychology · 2021Article
- Elevated Neutrophil to Lymphocyte Ratio in Older Adults with Cocaine Use Disorder as a Marker of Chronic Inflammation.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2020Article
- Peripheral blood microRNA levels in females with cocaine use disorder.Journal of psychiatric research · 2019Article
- Using a data science approach to predict cocaine use frequency from depressive symptoms.Drug and alcohol dependence · 2019Article
- Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review.Frontiers in psychiatry · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study explored anhedonia (lack of interest or pleasure in non-drug rewards) as a potentially modifiable individual difference associated with the effectiveness of Contingency Management (CM). It also tested the hypothesis that a dopaminergic drug, levodopa (L-DOPA), would improve the effectiveness of CM, particularly in individuals high in anhedonia. The study was a single-site, randomized, double-blind, parallel group, 12-week trial comparing L-DOPA with placebo, with both medication groups receiving voucher-based CM targeting cocaine-negative urines. Participants were N=85 treatment-seeking adults with CUD. Anhedonia was measured at baseline using a validated self-report measure and a progressive ratio behavioral measure. Treatment Effectiveness Score (TES) was defined as the total number of cocaine-negative urines submitted. Analyses based on Frequentist general linear models were not significant, but Bayesian analyses indicated a high probability (92.6%) that self-reported anhedonia was associated with poor treatment outcomes (lower TES). L-DOPA did not significantly improve outcomes, nor was the effect of L-DOPA moderated by anhedonia. While the study failed to replicate positive findings from previous studies of L-DOPA in combination with CM, it does provide preliminary evidence that anhedonia may be a modifiable individual difference associated with poorer CM outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.