ArticleScientific reports2016
Myelinating glia differentiation is regulated by extracellular matrix elasticity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 114 citations in OpenAlex.
- Myelin sheath lengths in the central nervous system scale to axon diameter via oligodendroglial Piezo1.PLoS biology · 2026Article
- Molecular Basis of Glia-ECM Interplay in Central Nervous System Homeostasis and Plasticity.Cells · 2026Review
- RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling.Glia · 2026Article
- ATM-kinase deficiency triggers early multi-compartment remodeling of the cerebellar microenvironment.Acta neuropathologica communications · 2026Article
- Tunable hydrogel-based micropillar arrays for myelination studies.Nature methods · 2026Article
- Shank3 related oligodendrocyte alterations in autism are restored by Erk pathway inhibition.Molecular psychiatry · 2026Article
- Mechanobiology of Myelin Generation/Regeneration in Health and Disease.Results and problems in cell differentiation · 2026Review
- Influences of physical stimulations on the migration and differentiation of Schwann cells involved in peripheral nerve repair.Cell adhesion & migration · 2025Review
- Tissue stiffness controls neuroblast migratory behavior and reprogramming during myelin repair.iScience · 2025Article
- Tight Spaces, Tighter Signals: Spatial Constraints as Drivers of Peripheral Myelination.Cells · 2025Article
- Functionalization of Two-Component Gelatinous Peptide/Reactive Oligomer Hydrogels with Small Molecular Amines for Enhanced Cellular Interaction.International journal of molecular sciences · 2025Article
- Tuina promotes nerve myelin regeneration in SNI rats through Piezo1/YAP/TAZ pathway.Journal of orthopaedic surgery and research · 2025Article
- Dynamically changing extracellular matrix stiffness drives Schwann cell phenotype.Matrix biology plus · 2025Article
- The extracellular matrix in peripheral nerve repair and regeneration: a narrative review of its role and therapeutic potential.Frontiers in neuroanatomy · 2025Review
- Demyelination and Remyelination: General Principles.Advances in neurobiology · 2025Review
- Developmental exposure of zebrafish to saxitoxin causes altered expression of genes associated with axonal growth.Neurotoxicology · 2024Article
- The Role of Mechanotransduction in Contact Inhibition of Locomotion and Proliferation.International journal of molecular sciences · 2024Review
- The mechanics of the retina: Müller glia role on retinal extracellular matrix and modelling.Frontiers in medicine · 2024Review
- Article
- Exploring an innovative decellularization protocol for porcine nerve grafts: a translational approach to peripheral nerve repair.Frontiers in neuroanatomy · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanical properties of living tissues have a significant impact on cell differentiation, but remain unexplored in the context of myelin formation and repair. In the PNS, the extracellular matrix (ECM) incorporates a basal lamina significantly denser than the loosely organized CNS matrix. Inhibition of non-muscle myosin II (NMII) enhances central but impairs peripheral myelination and NMII has been implicated in cellular responses to changes in the elasticity of the ECM. To directly evaluate whether mechanotransduction plays a role in glial cell differentiation, we cultured Schwann cells (SC) and oligodendrocytes (OL) on matrices of variable elastic modulus, mimicking either their native environment or conditions found in injured tissue. We found that a rigid, lesion-like matrix inhibited branching and differentiation of OL in NMII-dependent manner. By contrast, SC developed normally in both soft and stiffer matrices. Although SC differentiation was not significantly affected by changes in matrix stiffness alone, we found that expression of Krox-20 was potentiated on rigid matrices at high laminin concentration. These findings are relevant to the design of biomaterials to promote healing and regeneration in both CNS and PNS, via transplantation of glial progenitors or the implantation of tissue scaffolds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.