Evidence map›Paper›PMID 27646142›Full record

Trial reportBMC musculoskeletal disorders2016

Cemented compared to uncemented femoral stems in total hip replacement for displaced femoral neck fractures in the elderly: study protocol for a single-blinded, randomized controlled trial (CHANCE-trial).

Ghazi Chammout, Olle Muren, Henrik Bodén, Mats Salemyr, Olof Sköldenberg

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02247791 (Study of Prosthesis Choice in Older Patients With a Dislocated Femoral Neck Fracture of the Hip), which is not on this map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02247791 naunknown statusnot on this map

Study of Prosthesis Choice in Older Patients With a Dislocated Femoral Neck Fracture of the Hip

TypeinterventionalSponsorDanderyd HospitalRan2009 to 2024Enrolled140ConditionsHip FracturesArmsUncemented femoral stem, Cemented femoral stem
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Arthroplasties for hip fracture in adults.The Cochrane database of systematic reviews · 2022
    Pooled it
  3. Pooled it
  4. Long-term outcomes of cemented compared to uncemented femoral stems in total hip arthroplasty for displaced femoral neck fractures in elderly patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Trial
  5. Trial
  6. Article
  7. Article
  8. Observational
  9. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ghazi ChammoutKarolinska Institute, Department of Clinical Sciences at Danderyd hospital, Stockholm, S-182 88, Sweden.
Olle MurenKarolinska Institute, Department of Clinical Sciences at Danderyd hospital, Stockholm, S-182 88, Sweden.
Henrik BodénKarolinska Institute, Department of Clinical Sciences at Danderyd hospital, Stockholm, S-182 88, Sweden.
Mats SalemyrKarolinska Institute, Department of Clinical Sciences at Danderyd hospital, Stockholm, S-182 88, Sweden.
Olof SköldenbergKarolinska Institute, Department of Clinical Sciences at Danderyd hospital, Stockholm, S-182 88, Sweden. olof.skoldenberg@ki.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal hip replacement (THR) is the preferred method for the active and lucid elderly patient with a displaced femoral neck fracture (FNF). But controversy still exists regarding using cemented or uncemented stem in these patients. The aim of this study is to compare a cemented and uncemented femoral stem in patients 65-79 years treated surgically with THR for displaced FNF. METHODS/

designIn a single-centre, single-blinded, randomized controlled trial, we will include 140 patients aged 65-79 years with an acute displaced FNF and randomize them in a 1:1 ratio to a cemented tapered or a uncemented tapered hydroxyapatite - coated femoral stem. A cemented cup will be used in both groups. The patients will be blinded for allocation. The primary endpoints will be the incidence of all hip-related complications and health-related quality of life evaluated with EuroQol-5D (EQ-5D) index up to 2 years after surgery. Secondary outcomes will be overall mortality, general medical complications and hip function. The follow-up will be at 3 months, 1 and 2 years. Further follow-ups after end of study will be at 4 and 10 years. Results will be analysed using 95 % CI's for the effect size. A regression model will also be used to adjust for stratification factor. DISCUSSION: The ethical committee at Karolinska Institutet has approved the study. An interim analysis on the primary endpoints will be performed when half the sample size is included. The results from the study will be disseminated to the medical community via presentations and publications in relevant medical journals. The study will provide evidence if a cemented or uncemented femoral stem is preferable in THR for elderly patients with a displaced FNF.

trial registrationThe trial is registered at clinicaltrials.gov ( NCT02247791 ), October 21, 2013.

Indexed as

AgedArthroplasty, Replacement, HipFemoral Neck FracturesHip ProsthesisHumansIncidencePeriprosthetic FracturesPostoperative ComplicationsProsthesis DesignQuality of LifeSingle-Blind MethodTreatment OutcomeFemoral neck fractureFemoral stemOutcomeRandomized controlled trialTotal hip arthroplasty

Identifiers

PMID27646142
PMCPMC5028918

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.