ArticleGenetics2016
Evolution of Mutation Rates in Rapidly Adapting Asexual Populations.
Article in Genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Evolutionary dynamics under phenotypic uncertainty.bioRxiv : the preprint server for biology · 2026Article
- Unraveling the tempo and mode of horizontal gene transfer in bacteria.Trends in microbiology · 2025Review
- Population size interacts with reproductive longevity to shape the germline mutation rate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Population size interacts with reproductive longevity to shape the germline mutation rate.bioRxiv : the preprint server for biology · 2024Article
- Evolution of evolvability in rapidly adapting populations.Nature ecology & evolution · 2024Article
- Direct and indirect selection in a proofreading polymerase.bioRxiv : the preprint server for biology · 2024Article
- The evolutionary theory of cancer: challenges and potential solutions.Nature reviews. Cancer · 2024Review
- The divergence of mutation rates and spectra across the Tree of Life.EMBO reports · 2023Review
- Discovery of positive and purifying selection in metagenomic time series of hypermutator microbial populations.PLoS genetics · 2022Article
- Mutability of demographic noise in microbial range expansions.The ISME journal · 2021Article
- Dynamics of Adaptation During Three Years of Evolution Under Long-Term Stationary Phase.Molecular biology and evolution · 2021Article
- An interplay of resource availability, population size and mutation rate potentiates the evolution of metabolic signaling.BMC ecology and evolution · 2021Article
- Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations.eLife · 2021Article
- Antitumor Drugs and Their Targets.Molecules (Basel, Switzerland) · 2020Review
- Culture Volume Influences the Dynamics of Adaptation under Long-Term Stationary Phase.Genome biology and evolution · 2020Article
- Effect of arsenite and growth in biofilm conditions on the evolution ofMicrobial genomics · 2020Article
- Article
- Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes.Nucleic acids research · 2020Article
- Article
- Mutation bias and GC content shape antimutator invasions.Nature communications · 2019Article
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Authors and funding
2 authors.
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Abstract
Mutator and antimutator alleles often arise and spread in both natural microbial populations and laboratory evolution experiments. The evolutionary dynamics of these mutation rate modifiers are determined by indirect selection on linked beneficial and deleterious mutations. These indirect selection pressures have been the focus of much earlier theoretical and empirical work, but we still have a limited analytical understanding of how the interplay between hitchhiking and deleterious load influences the fates of modifier alleles. Our understanding is particularly limited when clonal interference is common, which is the regime of primary interest in laboratory microbial evolution experiments. Here, we calculate the fixation probability of a mutator or antimutator allele in a rapidly adapting asexual population, and we show how this quantity depends on the population size, the beneficial and deleterious mutation rates, and the strength of a typical driver mutation. In the absence of deleterious mutations, we find that clonal interference enhances the fixation probability of mutators, even as they provide a diminishing benefit to the overall rate of adaptation. When deleterious mutations are included, natural selection pushes the population toward a stable mutation rate that can be suboptimal for the adaptation of the population as a whole. The approach to this stable mutation rate is not necessarily monotonic: even in the absence of epistasis, selection can favor mutator and antimutator alleles that "overshoot" the stable mutation rate by substantial amounts.
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