ArticleNeuroImage2017
The neurogenesis of P1 and N1: A concurrent EEG/LFP study.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
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- Long-latency auditory evoked responses across species show increased amplitude during early life.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Effective connectivity between homologous cortices mediated by the corpus callosum: An axono-cortical evoked potentials study.Clinical neurophysiology practice · 2026Article
- Computational modeling reveals biological mechanisms underlying the whisker flick EEG.iScience · 2025Article
- Excitability Modulations of Somatosensory Perception Do Not Depend on Feedforward Neuronal Population Spikes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Alterations in topology, cost, and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury.Network neuroscience (Cambridge, Mass.) · 2025Article
- Distinct neocortical mechanisms underlie human SI responses to median nerve and laser-evoked peripheral activation.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Synaptic alterations in visual cortex reshape contrast-dependent gamma oscillations and inhibition-excitation ratio in a genetic mouse model of migraine.The journal of headache and pain · 2022Article
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- The anti-anxiety drug lorazepam changes implicit behaviors but not explicit evaluations of sense of agency under authoritative pressure: A functional magnetic resonance imaging study.Frontiers in psychology · 2022Article
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- Steady-state measures of visual suppression.PLoS computational biology · 2021Article
- Cross Laminar Traveling Components of Field Potentials due to Volume Conduction of Non-Traveling Neuronal Activity in Macaque Sensory Cortices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The missing N1 or jittered P2: Electrophysiological correlates of pattern glare in the time and frequency domain.The European journal of neuroscience · 2021Article
- Bone conducted responses in the neonatal rat auditory cortex.Scientific reports · 2021Article
- Neural markers of suppression in impaired binocular vision.NeuroImage · 2021Article
- Persistence of Neuronal Alterations in Alcohol-Dependent Patients at Conclusion of the Gold Standard Withdrawal Treatment: Evidence From ERPs.Frontiers in psychiatry · 2021Article
- Temporal Signatures of Criticality in Human Cortical Excitability as Probed by Early Somatosensory Responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- The Neural Origin of Nociceptive-Induced Gamma-Band Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
It is generally recognised that event related potentials (ERPs) of electroencephalogram (EEG) primarily reflect summed post-synaptic activity of the local pyramidal neural population(s). However, it is still not understood how the positive and negative deflections (e.g. P1, N1 etc) observed in ERP recordings are related to the underlying excitatory and inhibitory post-synaptic activity. We investigated the neurogenesis of P1 and N1 in ERPs by pharmacologically manipulating inhibitory post-synaptic activity in the somatosensory cortex of rodent, and concurrently recording EEG and local field potentials (LFPs). We found that the P1 wave in the ERP and LFP of the supragranular layers is determined solely by the excitatory post-synaptic activity of the local pyramidal neural population, as is the initial segment of the N1 wave across cortical depth. The later part of the N1 wave was modulated by inhibitory post-synaptic activity, with its peak and the pulse width increasing as inhibition was reduced. These findings suggest that the temporal delay of inhibition with respect to excitation observed in intracellular recordings is also reflected in extracellular field potentials (FPs), resulting in a temporal window during which only excitatory post-synaptic activity and leak channel activity are recorded in the ERP and evoked LFP time series. Based on these findings, we provide clarification on the interpretation of P1 and N1 in terms of the excitatory and inhibitory post-synaptic activities of the local pyramidal neural population(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.