ArticleAnnals of surgical oncology2017
Nodular Histologic Subtype and Ulceration are Tumor Factors Associated with High Risk of Recurrence in Sentinel Node-Negative Melanoma Patients.
Article in Annals of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 35 citations in OpenAlex.
- Development of a prognostic model for patients with nodular melanoma of the lower extremities: a study based on the SEER database.Archives of dermatological research · 2024Article
- Lymphatic system regulation of anti-cancer immunity and metastasis.Frontiers in immunology · 2024Review
- Metastatic multifocal melanoma of multiple organ systems: A case report.World journal of clinical cases · 2022Article
- Multivariate analysis of prognostic factors in patients with nodular melanoma.Journal of cancer research and clinical oncology · 2021Article
- Nodular malignant melanoma in vulvar skin without pigmentation: a case report.BMC women's health · 2021Article
- Head & neck melanoma: A 22-year experience of recurrence following sentinel lymph node biopsy.Laryngoscope investigative otolaryngology · 2021Article
- Prognostic significance of regression and mitotic rate in head and neck cutaneous melanoma.Laryngoscope investigative otolaryngology · 2021Article
- Web-based nomograms for predicting the prognosis of adolescent and young adult skin melanoma, a large population-based real-world analysis.Translational cancer research · 2020Article
- Prognostic Significance of RAS Mutations and P53 Expression in Cutaneous Squamous Cell Carcinomas.Genes · 2020Article
- The neutrophil-lymphocyte ratio and locoregional melanoma: a multicentre cohort study.Cancer immunology, immunotherapy : CII · 2020Article
- External validation of a prognostic model to predict survival of patients with sentinel node-negative melanoma.The British journal of surgery · 2019Article
- A nomogram for predicting survival in patients with nodular melanoma: A population-based study.Medicine · 2019Article
- Development and validation of a nomogram to predict recurrence and melanoma-specific mortality in patients with negative sentinel lymph nodes.The British journal of surgery · 2019Article
- Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy.Journal of the National Cancer Institute · 2019Article
- Tumour mutation status and melanoma recurrence following a negative sentinel lymph node biopsy.British journal of cancer · 2018Article
- Clinicopathological predictors of recurrence in nodular and superficial spreading cutaneous melanoma: a multivariate analysis of 214 cases.Journal of translational medicine · 2017Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince its introduction, the sentinel lymph node biopsy (SLNB) has become the standard staging procedure in clinical node-negative melanoma patients. A negative SLNB, however, does not guarantee a recurrence-free survival. Insight into metastatic patterns and risk factors for recurrence in SLNB negative melanoma patients can provide patient tailored guidelines.
methodsData concerning melanoma patients who underwent SLNB between 1996 and 2015 in a single center were prospectively collected. Cox regression analyses were used to determine variables associated with overall recurrence and distant first site of recurrence in SLNB-negative patients.
resultsIn 668 patients, SLNBs were performed between 1996 and 2015. Of these patients, 50.4 % were male and 49.6 % female with a median age of 55.2 (range 5.7-88.8) years. Median Breslow thickness was 2.2 (range 0.3-20) mm. The SLNB was positive in 27.8 % of patients. Recurrence rates were 53.2 % in SLNB-positive and 17.9 % in SLNB-negative patients (p < 0.001). For SLNB-negative patients, the site of first recurrence was distant in 58.5 %. Melanoma located in the head and neck region (hazard ratio 4.88, p = 0.003) and increasing Breslow thickness (hazard ratio 1.15, p = 0.013) were predictive for distant first site of recurrence in SLNB-negative patients. SLNB-negative patients with a nodular melanoma and ulceration had a recurrence rate of 43.1 %; the site of recurrence was distant in 64 % of these patients.
conclusionsThe recurrence rates of SLNB-negative nodular ulcerative melanoma patients approach those of SLNB-positive patients. Stringent follow-up is recommended in this subset of patients.
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