SynthesisBiological research for nursing2017
A Systematic Review of DNA Methylation and Preterm Birth in African American Women.
Synthesis in Biological research for nursing, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03013179 (Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Racial and ethnic representation in epigenomic studies of preterm birth: a systematic review.Epigenomics · 2021Pooled it
- Stress During Pregnancy and Epigenetic Modifications to Offspring DNA: A Systematic Review of Associations and Implications for Preterm Birth.The Journal of perinatal & neonatal nursingPooled it
- The Mediating Role of Social and Environmental Determinants of Health in the Association Between Race and Preterm Birth Risk.Journal of women's health (2002) · 2025Article
- Assessment of the histone mark-based epigenomic landscape in human myometrium at term pregnancy.eLife · 2025Article
- Documentation of Stigmatizing Language in Electronic Health Records and Birth Outcomes.Health equity · 2025Article
- Characterizing epigenetic aging in an adult sickle cell disease cohort.Blood advances · 2024Article
- The impact of DNA methylation as a factor of Adverse Pregnancy and Birth Outcomes (APBOs): a systematic review protocol.Systematic reviews · 2024Article
- Epigenetic Implications of Neighborhood Disorder and Psychological Distress among Pregnant Black Women.Western journal of nursing research · 2023Article
- DNA Methylation Patterns of Glucocorticoid Pathway Genes in Preterm Birth Among Black Women.Biological research for nursing · 2022Article
- The contribution of racism-related stress and adversity to disparities in birth outcomes: evidence and research recommendations.F&S reports · 2022Article
- The Vaginal Microbiota Composition and Genital Infections during and after Pregnancy among Women in Pemba Island, Tanzania.Microorganisms · 2022Article
- Stress Overload and DNA Methylation in African American Women in the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure Study.Epigenetics insights · 2022Article
- DNA methylation changes in African American women with a history of preterm birth from the InterGEN study.BMC genomic data · 2021Article
- Biological Embedding of Chronic Stress Across Two Generations Within Marginalized Communities.Child development perspectives · 2020Article
- Intergenerational Change in Birthweight: Effects of Foreign-born Status and Race/Ethnicity.Epidemiology (Cambridge, Mass.) · 2020Article
- Advances in Understanding the Causes and Consequences of Health Disparities in Aging Minorities.Current epidemiology reports · 2020Article
- DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.Croatian medical journal · 2020Article
- The color of health: how racism, segregation, and inequality affect the health and well-being of preterm infants and their families.Pediatric research · 2020Review
- Environmental Exposures, the Epigenome, and African American Women's Health.Journal of urban health : bulletin of the New York Academy of Medicine · 2019Review
- Explaining the Relationship Between Minority Group Status and Health Disparities: A Review of Selected Concepts.Health equity · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThe causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB.
methodsThe objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women.
resultsStudies ( N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB.
conclusionsFuture research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.