ArticleThe Journal of biological chemistry2016
Selenoprotein Gene Nomenclature.
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Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 2 of them syntheses that pooled it.
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138citing papers in PubMed, 2 pooled it
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Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it, 270 citations in OpenAlex.
- COVID-19 and Selenium Deficiency: a Systematic Review.Biological trace element research · 2022Pooled it
- Selenium Status in Patients with Chronic Liver Disease: A Systematic Review and Meta-Analysis.Nutrients · 2022Pooled it
- mRNA Rather than Protein Expression of Hepatic Selenoprotein H is More Sensitive to Short-term Low Aflatoxin BBiological trace element research · 2026Article
- Selenoproteins: Minute yet vital players governing cellular fate.Genes & diseases · 2026Review
- Selenium's Emergence from the Pool of Potentially Essential Trace Elements.Biological trace element research · 2026Review
- Article
- Selenium in the Preterm Infant: Are We Supplementing Enough in This Vulnerable Population?Nutrients · 2026Review
- Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis.Immunity · 2026Article
- Genetics of selenoproteins and selenoprotein metabolism - An overview of current concepts and emerging aspects.Redox biology · 2026Review
- Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods.BMC genomics · 2026Article
- Selenoprotein GPX3 regulates NADPH oxidase expression by inhibiting the MAPK signaling pathway and thereby attenuating the inflammatory response in renal ischemia-reperfusion injury.Genes & diseases · 2026Article
- GPR44-Dependent Regulation of the Selenoproteome by eIF4a3 in Murine Acute Myeloid Leukemia-Initiating Stem Cells.Biological trace element research · 2026Article
- Contributions of selenoproteins to breast cancer etiology and racial disparity.Cancer causes & control : CCC · 2026Article
- Selenium nanoparticles as a biological safe endodontic irrigant improving root canal sealing.BMC oral health · 2026Article
- Selenium and selenoproteins in age-related metabolic diseases: mechanistic insights and translational perspectives.Frontiers in nutrition · 2026Review
- Shared genetic architecture between Parkinson's disease and self-reported sleep-related traits implicates theSleep advances : a journal of the Sleep Research Society · 2026Article
- Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases.PLoS computational biology · 2026Article
- Iron and selenium: At the crossroads of development and death in oligodendrocytes.Archives of biochemistry and biophysics · 2025Review
- Review
- Selenium Compounds and Their Bioactivities: Molecular Mechanisms and Prospects for Functional Food and Therapeutic Applications.Plants (Basel, Switzerland) · 2025Review
78 more citing papers are in PubMed but not listed here.
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Authors and funding
53 authors at 20 institutions in 10 countries.
Vadim N GladyshevFrom the Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, vgladyshev@rics.bwh.harvard.edu.
Elias S Arnérthe Department of Medical Biochemistry and Biophysics (MBB), Division of Biochemistry, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Marla J Berrythe Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813.
Regina Brigelius-Flohéthe German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany.
Elspeth A Brufordthe HUGO Gene Nomenclature Committee (HGNC), European Bioinformatics Institute-European Molecular Biology Laboratory (EMBL-EBI), Hinxton CB10 1SD, United Kingdom.
Raymond F Burkthe Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University School of Medicine, Nashville, Tennessee 37232.
Bradley A Carlsonthe Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
Sergi Castellanothe Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Laurent Chavattethe Centre International de Recherche en Infectiologie, CIRI, INSERM U1111, and CNRS/ENS UMR5308, 69007 Lyon, France.
Marcus Conradthe Helmholtz Zentrum München, Institute of Developmental Genetics, 85764 Neuherberg, Germany.
Paul R Copelandthe Department of Biochemistry and Molecular Biology, Rutgers-Robert Wood Johnson Medical School, Piscataway, New Jersey 08854.
Alan M Diamondthe Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60607.
Donna M Driscollthe Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195.
Ana Ferreirothe Pathophysiology of Striated Muscles Laboratory, Unit of Functional and Adaptive Biology (BFA), University Paris Diderot, Sorbonne Paris Cité, BFA, UMR CNRS 8251, 75250 Paris, France.
Leopold Flohéthe Universidad de la República, Facultad de Medicina, Departamento de Bioquímica, 11800 Montevideo, Uruguay.
Fiona R Greenthe Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Roderic Guigóthe Centre for Genomic Regulation (CRG), 08003 Barcelona, Spain.
Diane E Handythe Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115.
Dolph L Hatfieldthe Molecular Biology of Selenium Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Institutes of Health, Bethesda, Maryland 20892.
John Heskeththe Institute for Cell and Molecular Biosciences, Newcastle University, Newcastle-upon-Tyne NE1 7RU, United Kingdom.
Peter R Hoffmannthe Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813.
Arne Holmgrenthe Department of Medical Biochemistry and Biophysics (MBB), Division of Biochemistry, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Robert J Hondalthe Department of Biochemistry, University of Vermont, Burlington, Vermont 05405.
Michael T Howardthe Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112.
Kaixun Huangthe Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, Peoples Republic of China.
Hwa-Young Kimthe Department of Biochemistry and Molecular Biology, Yeungnam University College of Medicine, Daegu 42415, South Korea.
Ick Young Kimthe College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea.
Josef Köhrlethe Institute for Experimental Endocrinology, Charité-Universitaetsmedizin Berlin, D-13353 Berlin, Germany.
Alain Krolthe Architecture et Réactivité de l'ARN, Université de Strasbourg, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Gregory V Kryukovthe KSQ Therapeutics, Cambridge, Massachusetts 02139.
Byeong Jae Leethe School of Biological Sciences, Seoul National University, Seoul 151-742, South Korea.
Byung Cheon Leethe College of Life Sciences and Biotechnology, Korea University, Seoul 02841, South Korea.
Xin Gen Leithe Department of Animal Science, Cornell University, Ithaca, New York 14853.
Qiong Liuthe Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Science, Shenzhen University, Shenzhen, 518060, Guangdong Province, Peoples Republic of China.
Alain Lescurethe Architecture et Réactivité de l'ARN, Université de Strasbourg, Centre National de la Recherche Scientifique, Institut de Biologie Moléculaire et Cellulaire, 67084 Strasbourg, France.
Alexei V LobanovFrom the Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Joseph Loscalzothe Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
Matilde Maiorinothe Department of Molecular Medicine, University of Padova, I-35121 Padova, Italy.
Marco MariottiFrom the Department of Medicine, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
K Sandeep Prabhuthe Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802.
Margaret P Raymanthe Department of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, United Kingdom.
Sharon Rozovskythe Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716.
Gustavo Salinasthe Cátedra de Inmunología, Facultad de Química, Instituto de Higiene, CP11600 Montevideo, Uruguay.
Edward E Schmidtthe Department of Microbiology and Immunology, Montana State University, Bozeman, Montana 59717.
Lutz Schomburgthe Institute for Experimental Endocrinology, Charité-Universitaetsmedizin Berlin, D-13353 Berlin, Germany.
Ulrich Schweizerthe Rheinische Friedrich-Wilhelms Universität Bonn, Institut für Biochemie und Molekularbiologie, 53115 Bonn, Germany.
Miljan Simonovićthe Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
Roger A Sundethe Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706.
Petra A Tsujithe Department of Biological Sciences, Towson University, Towson, Maryland 21252, and.
Susan Tweediethe HUGO Gene Nomenclature Committee (HGNC), European Bioinformatics Institute-European Molecular Biology Laboratory (EMBL-EBI), Hinxton CB10 1SD, United Kingdom.
Fulvio Ursinithe Department of Molecular Medicine, University of Padova, I-35121 Padova, Italy.
Philip D Whangerthe Department of Environmental and Molecular Toxicology, College of Agricultural Sciences, Oregon State University, Corvallis, Oregon 97331.
Yan Zhangthe Shenzhen Key Laboratory of Marine Biotechnology and Ecology, College of Life Science, Shenzhen University, Shenzhen, 518060, Guangdong Province, Peoples Republic of China.
Brigham and Women's Hospital · USCharité - Universitätsmedizin Berlin · DEEuropean Bioinformatics Institute · GBKarolinska Institutet · SEKorea University · KRShenzhen University · CNUniversity of Hawaiʻi at Mānoa · USUniversity of Illinois Chicago · USUniversity of Padua · ITBroad Institute · USCancer Genetics (United States) · USCentre for Genomic Regulation · ESCentre National de la Recherche Scientifique · FRCleveland Clinic · USCornell University · USGerman Institute of Human Nutrition · DEHarvard University · USHelmholtz Zentrum München · DEHuazhong University of Science and Technology · CNInserm · FR
Funding
Selenoproteins as Targets for Cancer PreventionR01CA080946 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2001 to 2018
$4.5MIDENTITY OF TERMINATOR AND SELENOCYSTEINE UGA CODONSR01GM061603 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GLADYSHEV, VADIM N. · 2000 to 2016
$4.0MSelenoprotein K modulates calcium-dependent signaling in immune cellsR01AI089999 · NIAID · UNIVERSITY OF HAWAII AT MANOA · PI HOFFMANN, PETER R · 2010 to 2020
$3.6MThe mechanism of selenium incorporation into selenocysteine in humans.R01GM097042 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2012 to 2021
$3.0MCellular Selenium Status and PGJ2 Metabolism (PA-17-078 supplement 2017)R01DK077152 · NIDDK · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2008 to 2018
$2.5MNomenclature of Human and Vertebrate GenesU41HG003345 · NHGRI · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BIRNEY, EWAN, BRUFORD, ELSPETH · 2013 to 2017
$2.4MThe effects of dietary selenium on translational control of protein synthesisR01GM114291 · NIGMS · UNIVERSITY OF UTAH · PI HOWARD, MICHAEL T · 2015 to 2022
$2.4MImpact of hepatocyte lineage life history dynamics on liver homeostasis in the agR01AG040020 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI GEDEON, TOMAS, SCHMIDT, EDWARD E · 2011 to 2015
$1.5MTargeting Leukemia Stem Cells with Dietary SeleniumR01CA162665 · NCI · PENNSYLVANIA STATE UNIVERSITY, THE · PI PRABHU, KUMBLE SANDEEP · 2012 to 2016
$1.5MThe role of MnSOD allelic variations in prostate cancer etiology and outcomeR01CA193497 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIAMOND, ALAN, PRINS, GAIL S · 2015 to 2017
$1.2MAnti-oxidant enzymes and prostate cancerR21CA182103 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DIAMOND, ALAN · 2014 to 2015
$473kRedox regulation in the hepatostatR21AG055022 · NIA · MONTANA STATE UNIVERSITY - BOZEMAN · PI ARNER, ELIAS S.J., NAGY, PETER · 2016 to 2017
$382kNCI NIH HHS R01 CA080946NCI NIH HHS R01 CA162665NCI NIH HHS R01 CA193497NCI NIH HHS R21 CA182103NHGRI NIH HHS U41 HG003345NIAID NIH HHS R01 AI089999NIA NIH HHS R01 AG040020NIA NIH HHS R21 AG055022NIDDK NIH HHS R01 DK077152NIGMS NIH HHS R01 GM061603NIGMS NIH HHS R01 GM097042NIGMS NIH HHS R01 GM114291
Abstract
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein-encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP), SELENOT (selenoprotein T, SELT), SELENOV (selenoprotein V, SELV), and SELENOW (selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.
Indexed as
HumansSelenoproteinsTerminology as TopicSelenoproteinsfunctiongene namegenomicsnomenclatureseleniumselenocysteineselenoproteinstructure-function
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