Evidence map›Paper›PMID 27645691›Full record

ArticleExperimental hematology2017

Pharmacological inhibition of AKT activity in human CD34

Sisi Chen, Rui Gao, Michihiro Kobayashi, Hao Yu, Chonghua Yao, Reuben Kapur, Mervin C Yoder, Yan Liu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Regulation of Hematopoietic Stem Cell Fate and Malignancy.International journal of molecular sciences · 2020
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sisi ChenDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Rui GaoDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Michihiro KobayashiDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Hao YuDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Chonghua YaoShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Reuben KapurDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Mervin C YoderDepartment of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA.
Yan LiuDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Pediatrics, Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: liu219@iu.edu.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USShanghai University of Traditional Chinese Medicine · CN

Funding

Novel Mechanisms of C-Kit Regulation in Mast CellsR01HL077177 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPUR, REUBEN · 2006 to 2016
$3.0M
Role of Vav and Rac in KIT oncogenesisR01HL081111 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPUR, REUBEN · 2009 to 2013
$1.9M
NHLBI NIH HHS R01 HL077177NHLBI NIH HHS R01 HL081111
6 · The paper itself

Abstract

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplantation remains limited by the inability to expand functional HSCs ex vivo. To determine the role of phosphoinositide 3-kinase (PI3K)/AKT signaling in human hematopoietic stem and progenitor cell (HSPC) maintenance, we examined the effect of genetic and pharmacological inhibition of AKT on human umbilical cord blood (UCB) CD34

Indexed as

Graft SurvivalHematopoietic Stem Cell TransplantationAnimalsAntigens, CD34BiomarkersCell CycleCell DifferentiationColony-Forming Units AssayErythroid CellsFetal BloodGene Knockdown TechniquesHematopoietic Stem CellsHumansImmunophenotypingMiceMice, SCIDAntigens, CD34BiomarkersProto-Oncogene Proteins c-aktRNA, Small Interfering

Identifiers

PMID27645691
PMCPMC5859321
OpenAlexW2519460404

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.