Observational studyJournal of clinical laboratory analysis2017
Associations among Serum Beta 2 Microglobulin, Malnutrition, Inflammation, and Advanced Cardiovascular Event in Patients with Chronic Kidney Disease.
Observational study in Journal of clinical laboratory analysis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis.Atherosclerosis · 2021Pooled it
- Bridging conventional clinical tests and advanced biomarkers for the early diagnosis of kidney disease progression.Pakistan journal of medical sciences · 2025Article
- Article
- Proteomic Assessment of the Risk of Secondary Cardiovascular Events among Individuals with CKD.Journal of the American Society of Nephrology : JASN · 2025Article
- Serum β2-microglobulin as an independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection.Scientific reports · 2024Article
- Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients.Diagnostics (Basel, Switzerland) · 2023Article
- β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats.Neural regeneration research · 2023Article
- Elevated serum beta-2 microglobulin level predicts short-term poor prognosis of patients withFrontiers in cellular and infection microbiology · 2023Article
- Association between serum β2-microglobulin and mortality in Japanese peritoneal dialysis patients: A cohort study.PloS one · 2022Article
- Review
- C-reactive protein-to-albumin ratio is an independent poor prognostic factor in newly diagnosed chronic lymphocytic leukaemia: A clinical analysis of 322 cases.Translational oncology · 2021Article
- Albumin-to-Fibrinogen Ratio as an Independent Prognostic Parameter in Untreated Chronic Lymphocytic Leukemia: A Retrospective Study of 191 Cases.Cancer research and treatment · 2019Article
- Genome-wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease.Nature communications · 2018Article
- The prognostic values of beta-2 microglobulin for risks of cardiovascular events and mortality in the elderly patients with isolated systolic hypertension.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2018Article
- Rediscovering Beta-2 Microglobulin As a Biomarker across the Spectrum of Kidney Diseases.Frontiers in medicine · 2017Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study examines the associations among serum β2 microglobulin (B2M), malnutrition, inflammation, and atherosclerosis (MIA) in those with chronic kidney disease (CKD).
methodsCKD patients who were followed in Taoyuan General Hospital from 2009 to 2015 were enrolled. Demographic and biochemical data, including B2M and C-reactive protein (CRP) were reviewed. The participants were stratified according to B2M tertiles. Adjusted hazard ratios (AHRs) and cumulative survival curves for death and MIA syndrome were evaluated by Cox hazard model and Kaplan-Meier method. We also calculated the area under the curve for the receiver operating characteristic curve (AUROC).
resultsFrom a total of 312 CKD patients, mean follow-up time was 39.7 months. Compared to those with lowest tertile of B2M, the highest tertile group had lower serum albumin, hemoglobin, and estimated glomerular filtration rate. After multivariate adjustment, the associations among tertiles of B2M, death or dialysis, cardiovascular events (CVEs), and MIA syndrome remained significant. The AHRs for the highest tertile group in death or dialysis, CVEs, and MIA syndrome were 25.91 and 65.84 and 152.50(all Ps <0.05).The AUROC for B2M in death or dialysis, CVEs, and MIA syndrome were greater than that for creatinine. The best cut-off value of B2M for predicting death or dialysis, CVEs, and MIA syndrome were 5.39 mg/dL(sensitivity: 67.1%, specificity 62.5%), 4.21 mg/dL(sensitivity: 85.1%, specificity 52.1%), and 5.40 mg/dL(sensitivity: 79.7%, specificity 64.1%).
conclusionsIn those with CKD, serum B2M was more sensitive than creatinine in predicting CVEs and MIA syndrome.
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