ArticleScientific reports2016
Transcriptome analysis of periodontitis-associated fibroblasts by CAGE sequencing identified DLX5 and RUNX2 long variant as novel regulators involved in periodontitis.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Amelogenin Phosphorylation Affects Key Regulatory Genes in the Enamel Organ.Calcified tissue international · 2026Review
- Bioengineering of Periodontal Tissues: Cell Therapy and Biomaterials Application.Bioengineering (Basel, Switzerland) · 2025Review
- DLX5 promotesGenes & diseases · 2023Article
- Organ Specificity and Heterogeneity of Cancer-Associated Fibroblasts in Colorectal Cancer.International journal of molecular sciences · 2021Review
- Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.Odontology · 2021Article
- Cell Type-Specific Decomposition of Gingival Tissue Transcriptomes.Journal of dental research · 2021Article
- DLX5 promotes osteosarcoma progression via activation of the NOTCH signaling pathway.American journal of cancer research · 2021Article
- FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.American journal of respiratory cell and molecular biology · 2020Article
- Effects of estrogen deficiency followed by streptozotocin-induced diabetes on periodontal tissues of female rats.Journal of molecular histology · 2020Article
- Host-microbe interactions: Profiles in the transcriptome, the proteome, and the metabolome.Periodontology 2000 · 2020Review
- TGF-β Signaling in Cellular Senescence and Aging-Related Pathology.International journal of molecular sciences · 2019Review
- Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study.Journal of oral biology and craniofacial researchArticle
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Authors and funding
15 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is affecting over half of the adult population, and represents a major public health problem. Previously, we isolated a subset of gingival fibroblasts (GFs) from periodontitis patients, designated as periodontitis-associated fibroblasts (PAFs), which were highly capable of collagen degradation. To elucidate their molecular profiles, GFs isolated form healthy and periodontitis-affected gingival tissues were analyzed by CAGE-seq and integrated with the FANTOM5 atlas. GFs from healthy gingival tissues displayed distinctive patterns of CAGE profiles as compared to fibroblasts from other organ sites and characterized by specific expression of developmentally important transcription factors such as BARX1, PAX9, LHX8, and DLX5. In addition, a novel long non-coding RNA associated with LHX8 was described. Furthermore, we identified DLX5 regulating expression of the long variant of RUNX2 transcript, which was specifically active in GFs but not in their periodontitis-affected counterparts. Knockdown of these factors in GFs resulted in altered expression of extracellular matrix (ECM) components. These results indicate activation of DLX5 and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis.
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