Evidence map›Paper›PMID 27645428›Full record

ArticleDrug development and industrial pharmacy2017

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.

Julien P Maincent, Laura K Najvar, William R Kirkpatrick, Siyuan Huang, Thomas F Patterson, Nathan P Wiederhold, Jay I Peters, Robert O Williams

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug development and industrial pharmacy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Julien P Maincenta College of Pharmacy , The University of Texas at Austin , Austin , TX , USA.
Laura K Najvarb University of Texas Health Science Center , San Antonio , TX , USA.
William R Kirkpatrickb University of Texas Health Science Center , San Antonio , TX , USA.
Siyuan Huanga College of Pharmacy , The University of Texas at Austin , Austin , TX , USA.
Thomas F Pattersonb University of Texas Health Science Center , San Antonio , TX , USA.
Nathan P Wiederholdb University of Texas Health Science Center , San Antonio , TX , USA.
Jay I Petersb University of Texas Health Science Center , San Antonio , TX , USA.
Robert O Williamsa College of Pharmacy , The University of Texas at Austin , Austin , TX , USA.
The University of Texas Health Science Center at San Antonio · USAustin College · USThe University of Texas at Austin · US

Funding

NIAID NIH HHS HHSN272201000038CNIAID NIH HHS HHSN272201000038I
6 · The paper itself

Abstract

Previously, modified release itraconazole in the form of a melt-extruded amorphous solid dispersion based on a pH dependent enteric polymer combined with hydrophilic additives (HME-ITZ), exhibited improved in vitro dissolution properties. These properties agreed with pharmacokinetic results in rats showing high and sustained itraconazole (ITZ) systemic levels. The objective of the present study was to better understand the best choice of rodent model for evaluating the pharmacokinetic and efficacy of this orally administered modified release ITZ dosage form against invasive Aspergillus fumigatus. A mouse model and a guinea pig model were investigated and compared to results previously published. In the mouse model, despite similar levels as previously reported values, plasma and lung levels were variable and fungal burden was not statistically different for placebo controls, HME-ITZ and Sporanox

Indexed as

Administration, OralAnimalsAntifungal AgentsAspergillus fumigatusCalorimetry, Differential ScanningDisease Models, AnimalGuinea PigsHydrogen-Ion ConcentrationHydrophobic and Hydrophilic InteractionsItraconazoleMiceRatsSolubilityAntifungal AgentsItraconazoleamorphous solid dispersionanimal model selectionenteric polymersIn vivo absorptionitraconazolemodified release

Identifiers

PMID27645428
PMCPMC6069995
OpenAlexW2521500143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.