ArticleBMC ophthalmology2016
Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy.
Article in BMC ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- AS-OCT assessment of limbal epithelial thickness at 12 months after pterygium surgery: a comparison of conjunctival limbal autograft and conjunctival flap techniques.International ophthalmology · 2026Article
- Anterior Segment Optical Coherence Tomography with Angiography for the Cornea and Ocular Surface.Journal of clinical medicine · 2026Review
- Corneal epithelium is altered in keratoconus and forme fruste keratoconus.Scientific reports · 2025Article
- Repeatability of Corneal Epithelial Thickness Map Using Anterior-Segment Optical Coherence Tomography in Normal and Corneal Disease Patients.Korean journal of ophthalmology : KJO · 2024Article
- Article
- Three-Month Comprehensive Outcomes of Topography-Guided LASIK Versus Keratorefractive Lenticule Extraction (KLEx): A Prospective Contralateral Study.Ophthalmology and therapy · 2024Article
- Corneal Epithelial Thickness Mapping: A Major Review.Journal of ophthalmology · 2024Review
- Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus.Journal of ophthalmology · 2023Article
- Article
- A Review of Imaging Biomarkers of the Ocular Surface.Eye & contact lens · 2020Review
- In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography.Translational vision science & technology · 2018Article
- Understanding Corneal Epithelial Thickness Mapping.Middle East African journal of ophthalmologyReview
- Role of corneal epithelial mapping, Corvis biomechanical index, and artificial intelligence-based tomographic biomechanical index in diagnosing spectrum of keratoconus.Oman journal of ophthalmologyArticle
- Corneal epithelial thickness profile at different corneal zones of normal eyes in a population sample from northern Iran: A cross-sectional study.Oman journal of ophthalmologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them.
methodsThirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location. Agreement was analyzed by mean difference (AS-OCT minus IVCM), 95 % limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis.
resultsThe average CET measured by AS-OCT and IVCM was 55.6 ± 4.0 μm and 51.9 ± 4.9 μm respectively. The value measured by IVCM was significantly lower than that measured by AS-OCT (P = 0.015). The average LET values tested by AS-OCT were 10.3 and 10.9 % less at nasal and temporal quadrant (nasal: P = 0.019, temporal: P = 0.003), and were similar as those measured by IVCM at superior and inferior quadrant. In subjects older than 40 years, CET and LET values measured by AS-OCT were significantly higher than those by IVCM. Such differences were not found in subjects ≤ 40 years old.
conclusionsCET values measured by IVCM are lower than those by AS-OCT, while LET values measured by two devices have good agreement. These two techniques have their own advantages in measuring epithelial thickness and are mutually complementary.
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