Evidence map›Paper›PMID 27645219›Full record

ReviewBreast cancer research : BCR2016

Beyond breast density: a review on the advancing role of parenchymal texture analysis in breast cancer risk assessment.

Aimilia Gastounioti, Emily F Conant, Despina Kontos

Abstract readReview
In one paragraph

Review in Breast cancer research : BCR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. Association between Participant Characteristics and Breast Parenchymal Texture Variation among Postmenopausal Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026
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  16. Malmö Breast ImaginG database: objectives and development.Journal of medical imaging (Bellingham, Wash.) · 2023
    Article
  17. Article
  18. Article
  19. Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aimilia GastouniotiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Emily F ConantDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Despina KontosDepartment of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA. Despina.Kontos@uphs.upenn.edu.

Funding

Penn Center for Innovation in Personalized Breast ScreeningU54CA163313 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ARMSTRONG, KATRINA, SCHNALL, MITCHELL D. · 2011 to 2017
$7.4M
Effect of Breast Density on Screening Recall with Digital Breast TomosynthesisR01CA161749 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KONTOS, DESPINA · 2012 to 2021
$3.6M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
NCI NIH HHS R01 CA161749NCI NIH HHS U24 CA189523NCI NIH HHS U54 CA163313
6 · The paper itself

Abstract

backgroundThe assessment of a woman's risk for developing breast cancer has become increasingly important for establishing personalized screening recommendations and forming preventive strategies. Studies have consistently shown a strong relationship between breast cancer risk and mammographic parenchymal patterns, typically assessed by percent mammographic density. This paper will review the advancing role of mammographic texture analysis as a potential novel approach to characterize the breast parenchymal tissue to augment conventional density assessment in breast cancer risk estimation. MAIN TEXT: The analysis of mammographic texture provides refined, localized descriptors of parenchymal tissue complexity. Currently, there is growing evidence in support of textural features having the potential to augment the typically dichotomized descriptors (dense or not dense) of area or volumetric measures of breast density in breast cancer risk assessment. Therefore, a substantial research effort has been devoted to automate mammographic texture analysis, with the aim of ultimately incorporating such quantitative measures into breast cancer risk assessment models. In this paper, we review current and emerging approaches in this field, summarizing key methodological details and related studies using novel computerized approaches. We also discuss research challenges for advancing the role of parenchymal texture analysis in breast cancer risk stratification and accelerating its clinical translation.

conclusionsThe objective is to provide a comprehensive reference for researchers in the field of parenchymal pattern analysis in breast cancer risk assessment, while indicating key directions for future research.

Indexed as

Breast DensityImage Processing, Computer-AssistedRadiographic Image Interpretation, Computer-AssistedBreast NeoplasmsFemaleGenetic Predisposition to DiseaseHumansMammographyMutationRisk AssessmentRisk FactorsBreast cancer riskDigital mammographyParenchymal texture analysisQuantitative breast imaging

Identifiers

PMID27645219
PMCPMC5029019

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.