ArticleEuropean biophysics journal : EBJ2017
Comparison of viscoelastic properties of cancer and normal thyroid cells on different stiffness substrates.
Article in European biophysics journal : EBJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
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- Gigantol Preserves Lens Biophysical Homeostasis by Restoring Cytoskeletal Integrity and Membrane Fluidity in a Diabetic Cataract Model.International journal of molecular sciences · 2026Article
- Mechanical Characterization of Stick Insect Tarsal Attachment Fluid Using Atomic Force Microscopy (AFM).Biomimetics (Basel, Switzerland) · 2026Article
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- A multiscale theory for mesenchymal cell migration in straight or curved channel confinement.Biophysical journal · 2025Article
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- Sound Touch Viscosity (STVi) for Thyroid Gland Evaluation in Healthy Individuals: A Pilot Study : STVi for Thyroid Gland Evaluation.Current medical imaging · 2025Article
- Tubulin-Targeted Therapy in Melanoma Increases the Cell Migration Potential by Activation of the Actomyosin Cytoskeleton─An In Vitro Study.ACS biomaterials science & engineering · 2024Article
- Single-cell mechanical assay unveils viscoelastic similarities in normal and neoplastic brain cells.Biophysical journal · 2024Article
- Mechanical properties of human tumour tissues and their implications for cancer development.Nature reviews. Physics · 2024Article
- A multiscale theory for spreading and migration of adhesion-reinforced mesenchymal cells.Journal of the Royal Society, Interface · 2023Article
- Peptide-based pore formation and cell membrane deformation: European Biophysics Journal Prizes at EBSA 2023.European biophysics journal : EBJ · 2023Article
- Insights in Cell Biomechanics through Atomic Force Microscopy.Materials (Basel, Switzerland) · 2023Review
- Assessment of Thyroid Stiffness and Viscosity in Autoimmune Thyroiditis Using Novel Ultrasound-Based Techniques.Biomedicines · 2023Article
- Viscosity Plane-Wave UltraSound (Vi PLUS) in the Evaluation of Thyroid Gland in Healthy Volunteers-A Preliminary Study.Diagnostics (Basel, Switzerland) · 2022Article
- Holmium Complex with Phospholipids asMolecules (Basel, Switzerland) · 2022Article
- Quantification of Thyroid Viscosity in Healthy Subjects Using Ultrasound Shear Wave Dispersion (Viscosity PLUS).Diagnostics (Basel, Switzerland) · 2022Article
- A PDE Model of Breast Tumor Progression in MMTV-PyMT Mice.Journal of personalized medicine · 2022Article
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2 authors.
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Abstract
We used atomic force microscopy (AFM) technique to measure the viscoelastic response of cancer and normal thyroid cells on different stiffness polyacrylamide gels. After applying a step in contact we recorded the stress relaxation of cells in order to measure their viscous and elastic properties. With the help of an extended version of the Hertz model, we could quantify for the first time by AFM the elastic modulus and the dynamic viscosity of cells on substrates with different stiffnesses. We have cultured anaplastic carcinoma and normal thyroid cells on three different substrates: polyacrylamide gels with elastic modulus in a range of 3-5 and 30-40 kPa and "infinitely" stiff Petri dishes. Whereas normal thyroid cells adapted their mechanical properties to different stiffness substrates, cancer cells were less affected by the surrounding stiffness. Normal cells changed the elastic modulus from 1.2 to 1.6 and to 2.6 kPa with increasing substrate stiffness; the dynamic viscosity values varied from 230 to 515 and to 470 Pa·s, accordingly. By contrast, the values for cancer cells were rather constant regardless of substrate stiffness (in average the elastic modulus was 1.3 kPa and the dynamic viscosity was 300 Pa·s). This difference in sensing and reacting to the mechanical properties of the substrate shows that normal and cancer cells interact differently with the neighboring tissue, which may be related to the ability of cancer cells to form metastases.
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