ArticlePhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2016
Quantitative mass spectrometry of unconventional human biological matrices.
Article in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Epidermal Patch Technologies for Integrated Healthcare and Infection Management.Advanced healthcare materials · 2026Review
- Adverse Effects of Airborne Heavy Metals on Human Skin Cells: Insights From Sebum Analysis of Indoor and Outdoor Workers.Journal of toxicology · 2026Article
- Hair analysis for monitoring adherence to inhaled respiratory medications: possibilities and limitations.European journal of clinical pharmacology · 2025Review
- Microneedle-based sampling of dermal interstitial fluid using a vacuum-assisted skin patch.Cell reports. Physical science · 2024Article
- Metabolomics Analysis and Diagnosis of Lung Cancer: Insights from Diverse Sample Types.International journal of medical sciences · 2024Review
- Analysis of Cannabinoids in Biological Specimens: An Update.International journal of environmental research and public health · 2023Review
- Analytical Approaches for the Determination of Buprenorphine, Methadone and Their Metabolites in Biological Matrices.Molecules (Basel, Switzerland) · 2022Review
- Metabolic phenotyping of tear fluid as a prognostic tool for personalised medicine exemplified by T2DM patients.The EPMA journal · 2022Article
- Free Amino Acid Alterations in Patients with Gynecological and Breast Cancer: A Review.Pharmaceuticals (Basel, Switzerland) · 2021Review
- A Review of GC-Based Analysis of Non-Invasive Biomarkers of Colorectal Cancer and Related Pathways.Journal of clinical medicine · 2020Review
- Blotting paper as a disposable tool for sampling chemical residues from skin surface.Journal of food and drug analysis · 2019Article
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2 authors.
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Abstract
The development of sensitive and versatile mass spectrometric methodology has fuelled interest in the analysis of metabolites and drugs in unconventional biological specimens. Here, we discuss the analysis of eight human matrices-hair, nail, breath, saliva, tears, meibum, nasal mucus and skin excretions (including sweat)-by mass spectrometry (MS). The use of such specimens brings a number of advantages, the most important being non-invasive sampling, the limited risk of adulteration and the ability to obtain information that complements blood and urine tests. The most often studied matrices are hair, breath and saliva. This review primarily focuses on endogenous (e.g. potential biomarkers, hormones) and exogenous (e.g. drugs, environmental contaminants) small molecules. The majority of analytical methods used chromatographic separation prior to MS; however, such a hyphenated methodology greatly limits analytical throughput. On the other hand, the mass spectrometric methods that exclude chromatographic separation are fast but suffer from matrix interferences. To enable development of quantitative assays for unconventional matrices, it is desirable to standardize the protocols for the analysis of each specimen and create appropriate certified reference materials. Overcoming these challenges will make analysis of unconventional human biological matrices more common in a clinical setting.This article is part of the themed issue 'Quantitative mass spectrometry'.
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