Evidence map›Paper›PMID 27644703›Full record

ReviewJournal of endocrinological investigation2017

Klinefelter syndrome (KS): genetics, clinical phenotype and hypogonadism.

M Bonomi, V Rochira, D Pasquali, G Balercia, E A Jannini, A Ferlin, Klinefelter ItaliaN Group (KING)

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.The Journal of clinical endocrinology and metabolism · 2026
    Pooled it
  2. Guideline
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  10. Article
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  14. Anogenital distance in patients with Klinefelter syndrome.Clinical and experimental reproductive medicine · 2026
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  17. Observational
  18. Review
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M BonomiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
V RochiraUnit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Via P. Giardini 1355, 41126, Modena, Italy. rochira.vincenzo@unimore.it.
D PasqualiDepartment of Cardiothoracic and Respiratory Science, Second University of Naples, Naples, Italy.
G BalerciaDivision of Endocrinology, Department of Clinical and Molecular Sciences, Umberto I Hospital, Polytechnic University of Marche, Via Conca 71, 60126, Ancona, Italy.
E A JanniniDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
A FerlinUnit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padova, Italy.
Klinefelter ItaliaN Group (KING)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Klinefelter Syndrome (KS) is characterized by an extreme heterogeneity in its clinical and genetic presentation. The relationship between clinical phenotype and genetic background has been partially disclosed; nevertheless, physicians are aware that several aspects concerning this issue are far to be fully understood. By improving our knowledge on the role of some genetic aspects as well as on the KS, patients' interindividual differences in terms of health status will result in a better management of this chromosomal disease. The aim of this review is to provide an update on both genetic and clinical phenotype and their interrelationships.

Indexed as

HumansHypogonadismKlinefelter SyndromePhenotypeAzoospermiaChromosome abnormalitiesHypergonadotropic hypogonadismKlinefelter syndromeKSMale infertilityTestosterone

Identifiers

PMID27644703
PMCPMC5269463

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.