Evidence map›Paper›PMID 27644327›Full record

ArticleMolecular and cellular biology2016

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance.

Sezin Dagdeviren, Dae Young Jung, Eunjung Lee, Randall H Friedline, Hye Lim Noh, Jong Hun Kim, Payal R Patel, Nicholas Tsitsilianos, Andrew V Tsitsilianos, Duy A Tran and 7 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular and cellular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 66 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Characterization of novelEvolutionary applications · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Sezin DagdevirenProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Dae Young JungProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Eunjung LeeProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Randall H FriedlineProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Hye Lim NohProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jong Hun KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Payal R PatelProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Nicholas TsitsilianosProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Andrew V TsitsilianosProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Duy A TranProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
George H TsougranisProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Caitlyn C KearnsProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Cecilia P UongProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jung Yeon KwonProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Werner MullerFaculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.
Ki Won LeeWorld Class University Biomodulation Major, Department of Agricultural Biotechnology, Seoul National University, Seoul, Republic of Korea.
Jason K KimProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA jason.kim@umassmed.edu.
University of Massachusetts Chan Medical School · USSeoul National University · KRAdvanced Institute of Convergence Technology · KRUniversity of Manchester · GB

Funding

Systems Biology of Insulin ResistanceR24DK090963 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2011 to 2014
$8.4M
UMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6M
UMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1M
Interleukin-10 and Regulation of Skeletal Muscle Insulin ActionR01DK080756 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2008 to 2012
$1.6M
Endoplasmic Reticulum Chaperone as a Regulator of Obesity and DiabetesR01DK079999 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, AMY S · 2009 to 2010
$776k
NIDDK NIH HHS R01 DK079999NIDDK NIH HHS R01 DK080756NIDDK NIH HHS R24 DK090963NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
6 · The paper itself

Abstract

Skeletal muscle insulin resistance is a major characteristic of obesity and type 2 diabetes. Although obesity-mediated inflammation is causally associated with insulin resistance, the underlying mechanism is unclear. Here, we examined the effects of chronic obesity in mice with muscle-specific overexpression of interleukin-10 (M

Indexed as

Insulin ResistanceAnimalsCells, CulturedDiabetes Mellitus, Type 2Diet, High-FatDisease Models, AnimalGene Knockout TechniquesGlucoseInterleukin-10LeptinMiceMuscle, SkeletalObesityReceptors, Interleukin-10Signal TransductionGlucoseIL10 protein, mouseInterleukin-10LeptinReceptors, Interleukin-10

Identifiers

PMID27644327
PMCPMC5108883
OpenAlexW2522920552

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.