Evidence map›Paper›PMID 27644325›Full record

ArticleMolecular and cellular biology2016

MIST1 Links Secretion and Stress as both Target and Regulator of the Unfolded Protein Response.

David A Hess, Katherine M Strelau, Anju Karki, Mei Jiang, Ana C Azevedo-Pouly, Ann-Hwee Lee, Tye G Deering, Chinh Q Hoang, Raymond J MacDonald, Stephen F Konieczny

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  7. Review
  8. Article
  9. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023
    Article
  10. Article
  11. Review
  12. ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

David A HessDepartment of Biological Sciences, Bindley Bioscience Center and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Katherine M StrelauDepartment of Biological Sciences, Bindley Bioscience Center and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Anju KarkiDepartment of Biological Sciences, Bindley Bioscience Center and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA.
Mei JiangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ana C Azevedo-PoulyDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ann-Hwee LeePathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA.ORCID http://orcid.org/0000-0001-8569-9786
Tye G DeeringDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Chinh Q HoangDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Raymond J MacDonaldDepartment of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID http://orcid.org/0000-0002-8576-766X
Stephen F KoniecznyDepartment of Biological Sciences, Bindley Bioscience Center and Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana, USA sfk@purdue.edu.ORCID http://orcid.org/0000-0002-3281-3714
The University of Texas Southwestern Medical Center · USPurdue University West Lafayette · USCornell University · US

Funding

Transgenic Mouse Core Facility Shared Resource (TMCF-SR)P30CA023168 · NCI · PURDUE UNIVERSITY WEST LAFAYETTE · PI Andrea L Kasinski · 1985 to 2026
$43.4M
Transcriptional Regulators of the Exocrine Pancreatic PhenotypeR01DK061220 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MACDONALD, RAYMOND J., MURTAUGH, LEWIS C · 2001 to 2019
$5.9M
Pancreas Transcription Factors and Disease Model SystemsR01DK055489 · NIDDK · PURDUE UNIVERSITY WEST LAFAYETTE · PI KONIECZNY, STEPHEN F · 2000 to 2017
$5.6M
Kras-Induced Cellular Plasticity in Pancreatic CancerR01CA124586 · NCI · PURDUE UNIVERSITY · PI KONIECZNY, STEPHEN F · 2008 to 2017
$3.1M
NCI NIH HHS P30 CA023168NCI NIH HHS R01 CA124586NIDDK NIH HHS R01 DK055489NIDDK NIH HHS R01 DK061220
6 · The paper itself

Abstract

Transcriptional networks that govern secretory cell specialization, including instructing cells to develop a unique cytoarchitecture, amass extensive protein synthesis machinery, and be embodied to respond to endoplasmic reticulum (ER) stress, remain largely uncharacterized. In this study, we discovered that the secretory cell transcription factor MIST1 (

Identifiers

PMID27644325
PMCPMC5108881
OpenAlexW2556471550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.