Evidence map›Paper›PMID 27644246›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016

γ-Aminobutyric acid inhibits the proliferation and increases oxaliplatin sensitivity in human colon cancer cells.

Lihua Song, Aiying Du, Ying Xiong, Jing Jiang, Yao Zhang, Zhaofeng Tian, Hongli Yan

Abstract read
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In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 49 citations in OpenAlex.

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  14. Live BiotherapeuticCancers · 2022
    Article
  15. Article
  16. Frontiers in pharmacology · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lihua SongThe Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240, China.
Aiying DuDepartment of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Ying XiongThe Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240, China.
Jing JiangThe Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240, China.
Yao ZhangThe Department of Food Science and Engineering, School of Agriculture and Biology, Shanghai Jiaotong University, Shanghai, 200240, China.
Zhaofeng TianDepartment of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China.
Hongli YanDepartment of Laboratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, 200433, China. hongliyan@smmu.edu.cn.
Shanghai Jiao Tong University · CNSecond Military Medical University · CNChanghai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-Aminobutyric acid (GABA) is a natural non-protein amino acid, which broadly exists in many plant parts and is widely used as an ingredient in the food industry. In mammals, it is widely distributed in central nervous system and non-neural tissues. In addition to a primary inhibitory neurotransmitter in the central nervous system, endogenous GABA content has been found to be elevated in neoplastic tissues in colon cancer. However, the effect of extraneous GABA on colon cancer has rarely been reported. In this study, we found the inhibitory effects of GABA on the proliferation of colon cancer cells (CCCs). The amino acid also suppressed metastasis of SW480 and SW620 cells. To further study the correlated mechanism, we analyzed the changes in cell cycle distribution and found that GABA suppressed cell cycle progression through G2/M or G1/S phase. Furthermore, RNA sequencing analysis revealed GABA-induced changes in the mRNA expression of 30 genes, including EGR1, MAPK4, NR4A1, Fos, and FosB, in all the three types of CCC. Importantly, GABA enhanced the anti-tumor efficacy of oxaliplatin (OXA) in subcutaneous xenograft tumor model in nude mice. The data suggest that GABA inhibits colon cancer cell proliferation perhaps by attenuating EGR1-NR4A1 axis, EGR1-Fos axis, and by disrupting MEK-EGR1 signaling pathway. This work reveals the pharmacological value of GABA derived from food and suggests that exogenous GABA might play an auxiliary role in polychemotherapy of colon cancer.

Indexed as

AnimalsAntineoplastic AgentsBase SequenceCell Line, TumorCell MovementCell ProliferationColonic NeoplasmsDrug SynergismEarly Growth Response Protein 1FemaleG1 Phase Cell Cycle CheckpointsG2 Phase Cell Cycle Checkpointsgamma-Aminobutyric AcidGene Expression Regulation, NeoplasticHCT116 CellsHumansAntineoplastic AgentsEarly Growth Response Protein 1EGR1 protein, humangamma-Aminobutyric AcidNR4A1 protein, humanNuclear Receptor Subfamily 4, Group A, Member 1Organoplatinum CompoundsOxaliplatinProto-Oncogene Proteins c-fosCell cycleCell proliferationColon cancer cellGABAMetastasisRNA sequencing

Identifiers

PMID27644246
OpenAlexW2522734760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.