Evidence map›Paper›PMID 27643868›Full record

ArticleBone marrow transplantation2016

Autoimmune hemolysis and immune thrombocytopenic purpura after cord blood transplantation may be life-threatening and warrants early therapy with rituximab.

V Bhatt, L Shune, E Lauer, M Lubin, S M Devlin, A Scaradavou, R Parameswaran, M A Perales, D M Ponce, S Mantha and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Bone marrow transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Immune Cytopenias after Ex Vivo CD34+-Selected Allogeneic Hematopoietic Cell Transplantation.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019
    Article
  10. Article
  11. Optimal Practices in Unrelated Donor Cord Blood Transplantation for Hematologic Malignancies.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

V BhattDepartment of Pharmacy, New York, NY, USA.
L ShuneAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
E LauerAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
M LubinAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
S M DevlinDepartment of Epidemiology and Biostatistics, New York, NY, USA.
A ScaradavouBone Marrow Transplantation Service, Department of Pediatrics, New York, NY, USA.
R ParameswaranDivision of Hematology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
M A PeralesAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
D M PonceAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
S ManthaDivision of Hematology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
N A KernanBone Marrow Transplantation Service, Department of Pediatrics, New York, NY, USA.
J N BarkerAdult Bone Marrow Transplantation Service, Department of Medicine, New York, NY, USA.
Cornell University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
T LYMPHOCYTE SUBSET FUNCTION POST-TRANSPLANTATIONP01CA023766 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAMER, ERIC G. · 1985 to 2023
$59.0M
NCI NIH HHS P01 CA023766NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Autoimmune hemolysis (AH) and immune thrombocytopenic purpura (ITP) are recognized complications after cord blood transplantation (CBT). We evaluated the incidence and characteristics of AH/ITP after double-unit CBT in a day 100 landmark analysis of 152 patients (median age 36 years, range 0.9-70 years) transplanted for hematologic malignancies with myeloablative or nonmyeloablative conditioning and calcineurin inhibitor (CNI)/mycophenolate mofetil. With a median 5.2-year (range 1.6-9.7 years) survivor follow-up, 10 patients developed autoimmune cytopenias (8 AH, 1 ITP, 1 both) at a median of 10.4 months (range 5.8-24.5) post CBT for a 7% cumulative incidence 3 years after the day 100 landmark. Six patients presented with severe disease (hemoglobin ⩽6 g/dL and/or platelets <20 × 10

Indexed as

AdolescentAdrenal Cortex HormonesAdultAgedAnemia, Hemolytic, AutoimmuneAntineoplastic Agents, ImmunologicalChildChild, PreschoolCord Blood Stem Cell TransplantationCritical IllnessFollow-Up StudiesHematologic NeoplasmsHemolysisHumansImmunosuppression TherapyInfantAdrenal Cortex HormonesAntineoplastic Agents, ImmunologicalRituximab

Identifiers

PMID27643868
PMCPMC5338737
OpenAlexW2521962099

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.