ArticlePloS one2016
Identification and Characterization of Cefotaxime Resistant Bacteria in Beef Cattle.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Tannic Acid and Copper-Modified ZIF-8 Metal Organic Framework as a Cefotaxime Delivery System for Antimicrobial ActivityTurkish journal of pharmaceutical sciences · 2026Article
- Frequency of Pseudomonas's Antibiotic Resistance and Virulence Genes in Poultry Meat.Veterinary medicine and science · 2025Article
- Multidrug-Resistant VirulentInternational journal of microbiology · 2025Article
- Environmental Antimicrobial Resistance: Implications for Food Safety and Public Health.Antibiotics (Basel, Switzerland) · 2024Review
- Isolation and Characterization of Extended-Spectrum β-Lactamase ProducingIndian journal of microbiology · 2024Article
- Comparison of methods proposed for monitoring cefotaxime-resistantApplied and environmental microbiology · 2024Article
- The fly route of extended-spectrum-β-lactamase-producingFrontiers in antibiotics · 2024Article
- Comparison of Cefotaxime-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- Assessment of virulence factors and antimicrobial resistance among the Pseudomonas aeruginosa strains isolated from animal meat and carcass samples.Veterinary medicine and science · 2023Article
- Transmission of antibiotic resistance at the wildlife-livestock interface.Communications biology · 2022Article
- An Evaluation of the Pathogenic Potential, and the Antimicrobial Resistance, ofMicroorganisms · 2022Article
- Occurrence of potentially zoonotic and cephalosporin resistant enteric bacteria among shelter dogs in the Central and South-Central Appalachia.BMC veterinary research · 2021Article
- Antimicrobial Resistance Patterns ofAntibiotics (Basel, Switzerland) · 2021Article
- Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study.Scientific reports · 2021Observational
- Periplanetasin-2 Enhances the Antibacterial Properties of Vancomycin or Chloramphenicol inJournal of microbiology and biotechnology · 2021Article
- A One Health Comparative Assessment of Antimicrobial Resistance in Generic and Extended-Spectrum Cephalosporin-ResistantMicroorganisms · 2020Article
- Antibiogram and beta-lactamase genes among cefotaxime resistant E. coli from wastewater treatment plant.Antimicrobial resistance and infection control · 2020Article
- Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production - a threat around the world.Heliyon · 2020Review
- Host genetic effects upon the early gut microbiota in a bovine model with graduated spectrum of genetic variation.The ISME journal · 2020Article
- Clinically Relevant Extended-Spectrum β-Lactamase-ProducingFrontiers in microbiology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Third-generation cephalosporins are an important class of antibiotics that are widely used in treatment of serious Gram-negative bacterial infections. In this study, we report the isolation of bacteria resistant to the third-generation cephalosporin cefotaxime from cattle with no previous cefotaxime antibiotic exposure. The prevalence of cefotaxime-resistant bacteria was examined by a combination of culture based and molecular typing methods in beef cattle (n = 1341) from 8 herds located in North Central Florida. The overall prevalence of cefotaxime-resistant bacteria was 15.8% (95% CI: 13.9, 17.8), varied between farms, and ranged from 5.2% to 100%. A subset of isolates (n = 23) was further characterized for the cefotaxime minimum inhibitory concentration (MIC) and antibiotic susceptibility against 10 different antibiotics, sequencing of nine β- lactamase genes, and species identification by 16S rRNA sequencing. Most of the bacterial isolates were resistant to cefotaxime (concentrations, > 64 μg/mL) and showed high levels of multi-drug resistance. Full length 16S rRNA sequences (~1300 bp) revealed that most of the isolates were not primary human or animal pathogens; rather were more typical of commensal, soil, or other environmental origin. Six extended spectrum β-lactamase (ESBL) genes identical to those in clinical human isolates were identified. Our study highlights the potential for carriage of cefotaxime resistance (including "human" ESBL genes) by the bacterial flora of food animals with no history of cefotaxime antibiotic exposure. A better understanding of the origin and transmission of resistance genes in these pre-harvest settings will be critical to development of strategies to prevent the spread of antimicrobial resistant microorganisms to hospitals and communities.
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